In chemical engineering, the materials that is drawn or stretched continuously its surface velocity initially increases with distance from the orifice. The extruded material is also simultaneously cooled to provide solidification through a water bath or spraying with a coolant. Due to such applications and others, the present study concerns with the film deposition of Casson nanoliquid heat and mass transfer bioconvection flow with homogeneous‐heterogeneous chemical reactions, entropy generation, thermal radiation and magnetic dipole effects. The mechanical system has been proposed by the governing equations and boundary conditions which are simplified by the use of suitable similarity transformations. Homotopy analysis method is applied to obtain the series solution of non‐linear ordinary differential equations. Physical behaviors of heat and mass transfer flow with entropy generation and spray rate are investigated through the embedded parameters. Velocity is decreased with Casson nanofluid, ferromagnetic, porosity and inertial parameters while temperature is increased with thermal radiation, ferromagnetic, porosity and inertial parameters. Concentration of chemical reaction is increased with Schmidt and Reynolds numbers as well as heterogeneous chemical reaction parameter while motile microorganisms concentration is decreased with bioconvection Lewis, Peclet, and Reynolds numbers. Entropy generation is increased with thermal radiation, diffusivity and porosity parameters while spray rate is decreased with high values of film size.