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Background Arsenic (As) is a contaminant of top public health concern, due to its range of detrimental health effects. Arsenic exposure has not been well-characterized among the US Hispanic populations and has been particularly understudied in this population during pregnancy. Methods As part of the MADRES ongoing pregnancy cohort of predominantly lower-income, Hispanic women in Los Angeles, CA, we examined levels of maternal first trimester urinary As, including total As and As metabolites (inorganic (iAs), monomethylated (MMA) and dimethylated As (DMA)), in relation to participant demographics, lifestyle characteristics, and rice/seafood consumption, to identify factors that may influence As exposure and its metabolites during pregnancy (N = 241). Results Total As concentrations ranged from low to high (0.8-506.2 μg/L, mean: 9.0 μg/L, SD: 32.9) in our study population. Foreign-born Hispanic women had 8.6% higher %DMA (95% CI: 3.3%, 13.9%) and −7.7% lower %iAs (95% CI: −12.6%, −2.9%) than non-Hispanic women. A similar trend was observed for US-born Hispanic women. In addition, maternal age was associated with 0.4% higher %iAs (95% CI: 0.1%, 0.6%) and 0.4% lower %DMA (95% CI: −0.7%, −0.1%) per year, which may indicate poor As methylation capacity. Conclusion Individual factors may predict As exposure and metabolism in pregnancy, and in turn, greater risk of adverse health effects.
Background Arsenic (As) is a contaminant of top public health concern, due to its range of detrimental health effects. Arsenic exposure has not been well-characterized among the US Hispanic populations and has been particularly understudied in this population during pregnancy. Methods As part of the MADRES ongoing pregnancy cohort of predominantly lower-income, Hispanic women in Los Angeles, CA, we examined levels of maternal first trimester urinary As, including total As and As metabolites (inorganic (iAs), monomethylated (MMA) and dimethylated As (DMA)), in relation to participant demographics, lifestyle characteristics, and rice/seafood consumption, to identify factors that may influence As exposure and its metabolites during pregnancy (N = 241). Results Total As concentrations ranged from low to high (0.8-506.2 μg/L, mean: 9.0 μg/L, SD: 32.9) in our study population. Foreign-born Hispanic women had 8.6% higher %DMA (95% CI: 3.3%, 13.9%) and −7.7% lower %iAs (95% CI: −12.6%, −2.9%) than non-Hispanic women. A similar trend was observed for US-born Hispanic women. In addition, maternal age was associated with 0.4% higher %iAs (95% CI: 0.1%, 0.6%) and 0.4% lower %DMA (95% CI: −0.7%, −0.1%) per year, which may indicate poor As methylation capacity. Conclusion Individual factors may predict As exposure and metabolism in pregnancy, and in turn, greater risk of adverse health effects.
While the desert ecosystem is highly dependent on the water resources that sustain it, the Fish Slough spring complex is an arid, spring-dependent wetland undergoing a multidecadal decline in spring outflow. This evaluation updates the source water forensics of the Fish Slough Spring complex, a substantial spring complex in the northern Owens Valley of the Basin and Range geomorphic provinces, in order to better understand the nature of the spring flow decline. The source of spring flow at Fish Slough was evaluated through an integration of the established geologic setting with measured groundwater elevations, and water quality and isotope chemistry compiled from both previously published sources and collection of new samples. While previous efforts to source the Fish Slough springs only considered potential source areas within the local geography, this evaluation considered a larger geographic extent for potential source areas to the spring water. The results infer that Fish Slough springs are sourced from multiple source water areas in hydraulic communication: a basin fill aquifer and warm, sodic spring systems with distinctive chemical signatures. Mixing from these sources occurs along two hypothesized flow paths, one from the northeast through the Tri-Valley area and one from the north and northwest through the Volcanic Tablelands. Northeast Spring has the strongest signature for Tri-Valley area waters, whereas the remaining Fish Slough Springs are comprised of a mixture of both flow paths. These conclusions have important implications for water management activities that have the potential to impact the desert ecosystem supported by these springs.
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