Los fibratos modifican la expresión hepática de colesterol 7-α-hidroxilasa, MDR3 y ABCG5 en pacientes con colelitiasis

Roglans, Núria; Novell, F; Zambón, Daniel; Ros, Emilio; Laguna, Juan Carlos; Sánchez, Rosa María Galán

doi:10.1016/s0214-9168(04)78988-3

Cited by 1 publication

(1 citation statement)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pparainduced responses in fish, including induction of acox, is previously found to be time-and tissue-specific (Mortensen et al, 2011;Urbatzka et al, 2015), or even unaffected by Ppara agonists (Madureira et al, 2017;Vieweg et al, 2018) which may be partially driven by the high clearance rate of fibrates in teleosts (Mimeault et al, 2005). However, ACOX gene expression was not significantly affected in response to fibrate treatment in human liver (Roglans et al, 2002), suggesting species differences in some of the responses.…”

Section: Figurementioning

confidence: 93%

Integrative omics-analysis of lipid metabolism regulation by peroxisome proliferator-activated receptor a and b agonists in male Atlantic cod

Eide

Goksøyr²,

Yadetie³

et al. 2023

Front. Physiol.

View full text Add to dashboard Cite

Lipid metabolism is essential in maintaining energy homeostasis in multicellular organisms. In vertebrates, the peroxisome proliferator-activated receptors (PPARs, NR1C) regulate the expression of many genes involved in these processes. Atlantic cod (Gadus morhua) is an important fish species in the North Atlantic ecosystem and in human nutrition, with a highly fatty liver. Here we study the involvement of Atlantic cod Ppar a and b subtypes in systemic regulation of lipid metabolism using two model agonists after in vivo exposure. WY-14,643, a specific PPARA ligand in mammals, activated cod Ppara1 and Ppara2 in vitro. In vivo, WY-14,643 caused a shift in lipid transport both at transcriptional and translational level in cod. However, WY-14,643 induced fewer genes in the fatty acid beta-oxidation pathway compared to that observed in rodents. Although GW501516 serves as a specific PPARB/D ligand in mammals, this compound activated cod Ppara1 and Ppara2 as well as Pparb in vitro. In vivo, it further induced transcription of Ppar target genes and caused changes in lipid composition of liver and plasma. The integrative approach provide a foundation for understanding how Ppars are engaged in regulating lipid metabolism in Atlantic cod physiology. We have shown that WY-14,643 and GW501516 activate Atlantic cod Ppara and Pparb, affect genes in lipid metabolism pathways, and induce changes in the lipid composition in plasma and liver microsomal membranes. Particularly, the combined transcriptomic, proteomics and lipidomics analyses revealed that effects of WY-14,643 on lipid metabolism are similar to what is known in mammalian studies, suggesting conservation of Ppara functions in mediating lipid metabolic processes in fish. The alterations in the lipid profiles observed after Ppar agonist exposure suggest that other chemicals with similar Ppar receptor affinities may cause disturbances in the lipid regulation of fish. Model organism: Atlantic cod (Gadus morhua). LSID: urn:lsid:zoobank.org:act:389BE401-2718-4CF2-BBAE-2E13A97A5E7B. COL Identifier: 6K72F.

show abstract