Los lunes al sol. Retrato social de historias de vida silenciadas

We present a new peptide‐macrocyclization strategy with an isobutylene graft. The reaction is mild and proceeds rapidly and efficiently both for linear and cyclic peptides. The resulting isobutylene‐grafted peptides possess improved passive membrane permeability due to the shielding of the polar backbone of the amides, as demonstrated by NMR spectroscopy and molecular dynamics simulations. The isobutylene‐stapled structures are fully stable in human plasma and in the presence of glutathione. This strategy can be applied to bioactive cyclic peptides such as somatostatin. Importantly, we found that structural preorganization forced by the isobutylene graft leads to a significant improvement in binding. The combined advantages of directness, selectivity, and smallness could allow application to peptide macrocyclization based on this attachment of the isobutylene graft.

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Enhanced Permeability and Binding Activity of Isobutylene‐Grafted Peptides

Sun

Compañón

Martínez‐Sáez

et al. 2017

ChemBioChem

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Triple Triangulación Compleja: análisis de discursos de formación y empleo

Montes

Domingo

2021

Educ. Real.

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Resumen: Las dificultades económicas y la precariedad laboral sufrida por España en la crisis, generó un incremento del desempleo de los mayores de 45 años. En este contexto, este estudio pretende comprender el drama social presente en los diferentes discursos que giran en torno a ello mediante el uso de un nuevo diseño metodológico: la triple triangulación compleja. Con este diseño se contrasta el discurso de cuatro fuentes: mayores de 45 años, datos oficiales, medios de comunicación y expertos. Los principales hallazgos muestran discursos dispares con algunos puntos de encuentro entre las fuentes. Se concluye que muchos factores que intervienen en el desempleo de los mayores, rebasan el ámbito de la formación, siendo un problema multidisciplinar.

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Los lunes al sol. Retrato social de historias de vida silenciadas

Abstract: making difficulties clearly visible and dignifying the collective from the social self-criticism of this reality.

Cited by 2 publications

References 4 publications

Enhanced Permeability and Binding Activity of Isobutylene‐Grafted Peptides

Enhanced Permeability and Binding Activity of Isobutylene‐Grafted Peptides

Triple Triangulación Compleja: análisis de discursos de formación y empleo

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