The analyzed indicators are in accord with the general tendency reported in the literature. The results revealed a general trend whereby the Classic inland sites display poorer life conditions than the Classic coastal sites. In the Postclassic period, this pattern changed because the frequencies of all stress indicators increased. The explanations regarding this tendency are related to the differential access to food resources between regions; coastal people had a varied diet and better sources of protein, taking into account the culture of alimentation, the type, and the sources (in general, fish) that have an important impact on the absorption of micronutrients and therefore greater impact on local health conditions. Also, it is plausible that they were able to access imported food through commerce (such as meat and vegetables/corn). The decline in health of the coastal people in the Postclassic period was probably associated with social stratification, increasing militarism, changes in the economic corpus, new pathogens, and the decline of the power structures prevailing throughout the Classic period.