We aimed to identify educational strategies and needs of parents of premature babies hospital in Cali, Colombia. We conducted a qualitative study of systematization of experiences focused on a process of mediated intervention. The axes of the systematization were: parental educational needs and improvement strategies for the follow-up program. The sample consisted of 11 mothers and parents who received education during a follow-up program, selected through an opinion-based sampling criterion. We conducted in-depth interviews with the parents and then used thematic content analysis. We found parental educational needs grouped into baby care: basic knowledge, behaviors and emotions, health and nutritional condition, and caregiver care. Improvement strategies suggested for the program focused on the use of information technologies, the parents’ school, and the integration of families