Losartan inhibits myosin isoform shift after myocardial infarction in rats

Zhang, Mei L.; Elkassem, Samer; Davidoff, A.; Salto, Kaoru; Keurs, H. E. D. J. Ter

doi:10.1016/s0022-2828(01)90543-7

Cited by 2 publications

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“…Myosin isoforms were assessed by modified pyrophosphate tube gel electrophoresis 26 . In brief, hearts were isolated from isoflurane‐anesthetized rats and perfused with HEPES buffer.…”

Section: Methodsmentioning

confidence: 99%

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Impaired myosin isoform shift and calcium transients contribute to cellular pathogenesis of rat cirrhotic cardiomyopathy

Honar

Liu

Zhang

et al. 2020

Liver International

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induced calcium release; dP/dT, Rate of rise of left ventricular pressure; dSL/ dt max , maximum velocities of shortening and relengthening; ECC, excitation-contraction coupling; E max , maximal cardiac elastance; FFR, force-frequency relation; FFT, fast fourier transformation; F max , maximum twitch force; F stst , steady-state twitch force; F tw , twitch force; I Ca,L , L-type Ca 2+ current; MHC, myosin heavy chain; PESP, post-extrasystolic potentiation; RMS SL , root mean square value of SL fluctuations; RyR, ryanodine receptor; SERCA, sarco/endoplasmic reticulum Ca 2+-ATPase; SL R , sarcomere length; SR, sarcoplasmic reticulum; t HR , time to half relaxation; t peak , time to peak shortening; TTP, time-to-peak Ca 2+ transient.

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“…Myosin isoforms were assessed by modified pyrophosphate tube gel electrophoresis 26 . In brief, hearts were isolated from isoflurane‐anesthetized rats and perfused with HEPES buffer.…”

Section: Methodsmentioning

confidence: 99%

“…Protein samples (4‐5 mg) were subjected to gel electrophoresis with Coomassie blue staining. The density of myosin isoform bands was quantified using Gaussian curve fitting (MATLAB ® ), and expressed as percentage of the total area under the curves 26 …”

Section: Methodsmentioning

confidence: 99%

Impaired myosin isoform shift and calcium transients contribute to cellular pathogenesis of rat cirrhotic cardiomyopathy

Honar

Liu

Zhang

et al. 2020

Liver International

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“…In fact, the shift from α-to β-MyHC reported after MI has been correlated with LV dysfunction and consequentially poor clinical prognoses [22][23][24]. Although this can be attributed to a multitude of factors, well-documented findings illustrate the shift as an adaptive response to chronic overload conditions resulting from the MI itself [25][26][27].…”

Section: Post-myocardial Infarction (Mi) Myhc Isoform Shiftmentioning

confidence: 99%

Post-Myocardial Infarction and Exercise Training on Myosin Heavy Chain and Cardiac Function

Chung¹,

Zhang²,

Cruger³

2019

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Myosin heavy chain (MyHC) acts as the chemical-mechanical transducer of motion in muscle fibers by converting energy from ATP into the sliding myofilaments. The isoform α-MyHC has about three-fold higher ATPase activity than the isoform β-MyHC. In the failing heart, however, α-MyHC expression is profoundly downregulated and β-MyHC is reciprocally upregulated. The shift of MyHC isoforms contributes to the development of myocardial systolic dysfunction and cardiomyopathy. Although this can be attributed to a multitude of factors, well-documented findings illustrate the shift as an adaptive response to chronic overload conditions resulting from the MI itself. Endurance training has been well documented as a leading technique to attenuate unfavorable post-MI cardiac dysfunction. Endurance training studies consisting of aerobic-style exercises prompts beneficial effects on cardiac function by attenuating myocardial MyHC remodeling following MI and congestive heart failure. However, endurance training promotes eccentric cardiac hypertrophy characterized by the addition of sarcomeres in series, elongation of the myocyte cell, and a consequential increase in cell size and chamber diameter, which may worsen the MI-induced cardiac dilation. In contrast, resistance training stimulates pressure-overload hemodynamic characteristics. Concentric cardiac hypertrophy is a unique resistance training adaptation characterized by cardiac wall thickening without cardiac chamber expansion. Whether resistance training also beneficially reverses MI-induced detrimental α-to β-MyHC shift and improves post-MI systolic function remains to be elucidated.

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Losartan inhibits myosin isoform shift after myocardial infarction in rats

Cited by 2 publications

References 0 publications

Impaired myosin isoform shift and calcium transients contribute to cellular pathogenesis of rat cirrhotic cardiomyopathy

Impaired myosin isoform shift and calcium transients contribute to cellular pathogenesis of rat cirrhotic cardiomyopathy

Post-Myocardial Infarction and Exercise Training on Myosin Heavy Chain and Cardiac Function

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