This report examines the potential economic benefits of physical activity. Specifically, it looks at the potential gains in economic output and healthcare expenditure savings under different physical activity improvement scenarios at the population level. This study contributes to the existing literature in three ways. First, we synthesise and evaluate, in a systematic manner, the existing empirical evidence on the association between physical activity and mortality risk, using a meta-analytical approach to adjust for study heterogeneity and potential publication bias in the literature. Second, using large-scale, international workplace survey data, we quantify the associations between physical activity and workplace performance, with a specific focus on levels of sickness absence and levels of presenteeism. Finally, we examine the macroeconomic effects of reduced premature mortality and reductions in sickness absence and presenteeism associated with making the population of a country more physically active. The report will be of interest to policymakers in the fields of public health and at the same time to a much broader spectrum of readers, including private sector agents, in particular in the health and life insurance domains. The Vitality Group, part of Discovery Ltd, commissioned RAND Europe to carry out this research project. RAND Europe had full editorial control and independence of the analyses performed and presented in this report. This work informs the public good and should not be taken as a commercial endorsement. RAND Europe is an independent, not-for-profit policy research organisation that aims to improve policy-and decision making in the public interest through research and analysis. This report has been peer-reviewed in accordance with RAND's quality assurance standards. For more information about RAND Europe or this document, please contact Marco Hafner