2000
DOI: 10.1016/s0165-4608(00)00212-0
|View full text |Cite
|
Sign up to set email alerts
|

Loss of 14q and 22q in Gastrointestinal Stromal Tumors (Pacemaker Cell Tumors)

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

7
55
0
3

Year Published

2001
2001
2010
2010

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 71 publications
(65 citation statements)
references
References 22 publications
7
55
0
3
Order By: Relevance
“…Interestingly, there have been no known oncogenes that map to 5p. In previous investigations of GIST, the most frequent chromosomal abnormalities were observed in losses of chromosomes 14 and 22 by a conventional banding method (Breiner et al, 2000), as also observed in GIST-T1, which may contribute to early GIST pathogenesis. As reported previously on the mutation of c-kit gene (Hirota et al, 1998;Taniguchi et al, 1999), our preliminary sequence analysis of exon 11 of the c-kit gene on GIST-T1 cells by direct sequence determination revealed a heterozygous deletion of 57 bases.…”
Section: Taguchi Et Almentioning
confidence: 60%
“…Interestingly, there have been no known oncogenes that map to 5p. In previous investigations of GIST, the most frequent chromosomal abnormalities were observed in losses of chromosomes 14 and 22 by a conventional banding method (Breiner et al, 2000), as also observed in GIST-T1, which may contribute to early GIST pathogenesis. As reported previously on the mutation of c-kit gene (Hirota et al, 1998;Taniguchi et al, 1999), our preliminary sequence analysis of exon 11 of the c-kit gene on GIST-T1 cells by direct sequence determination revealed a heterozygous deletion of 57 bases.…”
Section: Taguchi Et Almentioning
confidence: 60%
“…All three tumors had losses of whole 1p; LMS 43 also had a gain of whole 1q and LMS 45 also had a loss of chromosome 14. These profiles are suggestive of GIST (Breiner et al, 2000;Derré et al, 2000;El-Rifai et al, 1996. Moreover, a number of GIST can express muscular markers Sircar et al, 1999).…”
Section: Discussionmentioning
confidence: 98%
“…This suggests that these genetics aberrations may be important in both early tumor development and progression. [8][9][10][11][12][13][14][15][16][17][18][19][20] Gunawan et al 8 have recently proposed an oncogenetic tree model identifying three major cytogenetic pathways in 203 primary GISTs: one initiated by À14q, one by À1p and another by À22q, with different biologic and clinical behavior. GISTs involving the À14q pathway were predominantly gastric tumors with stable karyotype and more favorable clinical course.…”
Section: Discussionmentioning
confidence: 99%
“…These chromosomal losses may represent an underlying pathogenetic event resulting in the inactivation or haploinsufficiency of tumor suppressor genes. [8][9][10][11][12][13][14][15][16][17][18][19][20] However, the biologic significance of these genetic alterations, as well as their clinical implications, remains unknown. To address this issue, we performed an integrative analysis of gene expression profiling and high-resolution genomic copy number in 25 GIST samples to investigate the relationship between karyotype and gene expression profile, and to identify new haploinsufficient tumor suppressor genes involved in GIST pathogenesis and tumor progression.…”
mentioning
confidence: 99%