Loss of Apelin Exacerbates Myocardial Infarction Adverse Remodeling and Ischemia‐reperfusion Injury: Therapeutic Potential of Synthetic Apelin Analogues

Wang, Wang; McKinnie, Shaun M. K.; Patel, Vaibhav; Haddad, George; Wang, Zuocheng; Zhabyeyev, Pavel; Das, Sajal Kumar; Basu, Ratnadeep; McLean, Brent A.; Kandalam, Vijay; Penninger, Josef; Kassiri, Zamaneh; Vederas, John C.; Murray, Allan G.; Oudit, Gavin Y.

doi:10.1161/jaha.113.000249

Cited by 186 publications

(192 citation statements)

References 55 publications

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“…In line with these findings, we observe that the lack of apelin induces a deleterious microenvironment characterized by an increase in inflammatory mediators and immune cell infiltration after MI. Although apelin-deficient mice have normal cardiac function, these mice exhibit a susceptibility to heart failure and reduced heart contractility in aging mice (40,41). Lymphatic vessel dysfunction associated with the accumulation of immune cells in cardiac tissue could in part explain the increase of susceptibility to MI in apelin-deficient mice.…”

Section: Discussionmentioning

confidence: 99%

Apelin modulates pathological remodeling of lymphatic endothelium after myocardial infarction

Tatin¹,

Renaud-Gabardos²,

Godet³

et al. 2017

JCI Insight

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Section: Discussionmentioning

confidence: 99%

Apelin modulates pathological remodeling of lymphatic endothelium after myocardial infarction

Tatin¹,

Renaud-Gabardos²,

Godet³

et al. 2017

JCI Insight

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“…cardiac or renal, but also to the various treatments and therapies. In response to Q5, T2 was thus related to research: in disease studies [30][31][32][33][34][35][36][37], to compare care and coding [38][39][40], but also in monitoring of patients over time and the survival rate [31,[41][42][43][44]. Survival rate forms part of a trajectory concept.…”

Section: Discussionmentioning

confidence: 99%

“…There is also emergency management before hospital admission, including transport and first aid. Then there is care at admission, medication management [44] and associated costs-here the trajectory concept emerges. There is also an aspect regarding the effectiveness of the measures implemented [46][47][48][49][50][51][52] and the different treatments [53][54][55].…”

Section: Discussionmentioning

confidence: 99%

Patient healthcare trajectory. An essential monitoring tool: a systematic review

Pinaire

Azé

Bringay

et al. 2017

Health Inf Sci Syst

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Background: Patient healthcare trajectory is a recent emergent topic in the literature, encompassing broad concepts. However, the rationale for studying patients' trajectories, and how this trajectory concept is defined remains a public health challenge. Our research was focused on patients' trajectories based on disease management and care, while also considering medico-economic aspects of the associated management. We illustrated this concept with an example: a myocardial infarction (MI) occurring in a patient's hospital trajectory of care. The patient follow-up was traced via the prospective payment system. We applied a semi-automatic text mining process to conduct a comprehensive review of patient healthcare trajectory studies. This review investigated how the concept of trajectory is defined, studied and what it achieves.Methods: We performed a PubMed search to identify reports that had been published in peer-reviewed journals between January 1, 2000 and October 31, 2015. Fourteen search questions were formulated to guide our review. A semi-automatic text mining process based on a semantic approach was performed to conduct a comprehensive review of patient healthcare trajectory studies. Text mining techniques were used to explore the corpus in a semantic perspective in order to answer non-a priori questions. Complementary review methods on a selected subset were used to answer a priori questions.Results: Among the 33,514 publications initially selected for analysis, only 70 relevant articles were semi-automatically extracted and thoroughly analysed. Oncology is particularly prevalent due to its already well-established processes of care. For the trajectory thema, 80% of articles were distributed in 11 clusters. These clusters contain distinct semantic information, for example health outcomes (29%), care process (26%) and administrative and financial aspects (16%). Conclusion:This literature review highlights the recent interest in the trajectory concept. The approach is also gradually being used to monitor trajectories of care for chronic diseases such as diabetes, organ failure or coronary artery and MI trajectory of care, to improve care and reduce costs. Patient trajectory is undoubtedly an essential approach to be further explored in order to improve healthcare monitoring.

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“…Apelin is synthesized as a 77-amino acid peptide processed into various C-terminal fragments, including apelin-36, -19, -17, -13, -12, and [Pyr1]-apelin-13. Apelin-13 is the most stable amongst Resistin-induced cardiomyocyte hypertrophy is inhibited by apelin through the inactivation of extracellular signal-regulated kinase signaling pathway in H9c2 embryonic rat cardiomyocytes them (20,21). Deficiency of apelin exacerbates MI adverse remodeling and ischemia-reperfusion (I/R) injury (21).…”

Section: Introductionmentioning

confidence: 99%

“…Apelin-13 is the most stable amongst Resistin-induced cardiomyocyte hypertrophy is inhibited by apelin through the inactivation of extracellular signal-regulated kinase signaling pathway in H9c2 embryonic rat cardiomyocytes them (20,21). Deficiency of apelin exacerbates MI adverse remodeling and ischemia-reperfusion (I/R) injury (21). Treatment with apelin promotes myocardial angiogenesis and improves cardiac function in post-MI mice (22).…”

Section: Introductionmentioning

confidence: 99%

Resistin-induced cardiomyocyte hypertrophy is inhibited by apelin through the inactivation of extracellular signal-regulated kinase signaling pathway in H9c2 embryonic rat cardiomyocytes

et al. 2016

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Abstract. It has been reported that resistin induces, whereas apelin inhibits cardiac hypertrophy. However, the underlying molecular mechanisms of apelin inhibiting resistin-induced cardiac hypertrophy remain unclear. The aim of the current study is to investigate the effects of apelin on resistin-induced cardiomyocyte hypertrophy and elucidate the underlying molecular mechanism. H9c2 cells were used in the present study, and cell surface area and protein synthesis were evaluated. Reverse transcription-quantitative polymerase chain reaction was performed to analyze the expression levels of hypertrophic markers, brain natriuretic peptide (BNP) and β-myosin heavy chain (β-MHC). In addition, western blotting was conducted to examine phosphorylation of extracellular signal-regulated kinase (ERK)1/2. Following treatment of H9c2 cells with resistin, cell surface area, protein synthesis, and BNP and β-MHC mRNA expression levels were increased. Subsequent to co-treatment of H9c2 cells with apelin and resistin, lead to the inhibition of resistin-induced hypertrophic effects by apelin. In addition, treatment with resistin increased phosphorylation of ERK1/2, whereas pretreatment with apelin decreased phosphorylation of ERK1/2, which was increased by resistin. These results indicate that resistin-induced cardiac hypertrophy is inhibited by apelin via inactivation of ERK1/2 cell signaling.

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Loss of Apelin Exacerbates Myocardial Infarction Adverse Remodeling and Ischemia‐reperfusion Injury: Therapeutic Potential of Synthetic Apelin Analogues

Cited by 186 publications

References 55 publications

Apelin modulates pathological remodeling of lymphatic endothelium after myocardial infarction

Apelin modulates pathological remodeling of lymphatic endothelium after myocardial infarction

Patient healthcare trajectory. An essential monitoring tool: a systematic review

Resistin-induced cardiomyocyte hypertrophy is inhibited by apelin through the inactivation of extracellular signal-regulated kinase signaling pathway in H9c2 embryonic rat cardiomyocytes

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