Loss of artemisinin produced by Artemisia annua L. to the soil environment

Jessing, Karina K.; Cedergreen, Nina; Mayer, Philipp; Libous-Bailey, Lynn; Strobel, Bjarne W.; Rimando, Agnes M.; Duke, Stephen O.

doi:10.1016/j.indcrop.2012.06.033

Cited by 25 publications

(10 citation statements)

References 32 publications

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“…It is synthesized and sequestered in glandular trichomes located on the leaves and flowers [51]. It can also be excreted by the roots or root hairs, but only at the beginning of the growing season; therefore, dead leaves are the major source of artemisinin in soils [52]. Artemisinin is also lost from annual wormwood by rain runoff but to a minor degree (<0.5%),.…”

Section: Artemisininmentioning

confidence: 99%

Allelochemicals as Bioherbicides — Present and Perspectives

Sołtys¹,

Krasuska²,

Bogatek³

et al. 2013

Herbicides - Current Research and Case Studies in Use

170

149

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Section: Artemisininmentioning

confidence: 99%

Allelochemicals as Bioherbicides — Present and Perspectives

Sołtys¹,

Krasuska²,

Bogatek³

et al. 2013

Herbicides - Current Research and Case Studies in Use

170

149

View full text Add to dashboard Cite

“…Although recently small amounts of root-produced artemisinin were reported (Jessing et al 2013), generally, AN and its precursors are not detectable in the roots of A. annua Janick 1995, 1996), yet roots seem to play a pivotal role in regulating production of this important specialty molecule. When in vitro-cultured A. annua shoots developed roots, shoots produced more AN than unrooted shoots (Ferreira and Janick 1996), a result confirmed by Nguyen et al (2013).…”

Section: Introductionmentioning

confidence: 99%

Root regulation of artemisinin production in Artemisia annua: trichome and metabolite evidence

Wang

Towler

Weathers

2016

Planta

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Roots of plants with high artemisinin-producing leaves increased leaf production of artemisinin in low-producing plants and vice versa indicating roots are involved in controlling artemisinin biosynthesis in shoots. The anti-malarial sesquiterpene, artemisinin, is produced and stored in glandular trichomes (GLTs) of Artemisia annua. Evidence suggested roots, which produce no significant artemisinin nor precursor compounds, regulate production of artemisinin biosynthesis in the leaves. Using grafting, we studied the relationship between rootstock and scion by measuring GLTs and five artemisinic metabolites (artemisinin, deoxyartemisinin, dihydroartemisinic acid, artemisinic acid, arteannuin B) in scions of ungrafted, self-grafted, and cross-grafted plants among three cultivars: S and 15 both having GLTs with artemisinin at 1.49 and 0.57 %, respectively, and G producing neither GLTs nor detectable artemisinin. All artemisinin-producing self-grafts, e.g., S/S (scion/rootstock) and 15/15, produced more artemisinin than ungrafted plants, likely from grafting stress. S/S grafts also produced more GLTs. The 15/S grafts produced more artemisinin than S/15, suggesting rootstocks from high producing S plants stimulated artemisinin production in 15 scions. S/15 grafts yielded less artemisinin than S/S, but more than either 15/15 or ungrafted n15 and nS; S/15 grafts also had a lower density of GLTs than S/S, suggesting rootstock inhibition of the scion. The S rootstock induced trace artemisinin production in G scions, but did not induce GLT formation in G/S grafts. Different grafts exhibited different trichome morphologies and effects on artemisinic pathway flux. This study provides new information regarding the role of roots in GLT development and artemisinin production in this important medicinal plant.

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“…Sweet wormwood (Artemisia annua) produces the active compound artemisinin (Figure 2), which is a sesquiterpene with a peroxide group. The compound is known from traditional Chinese medicine in China and is grown in several continents, and its impact on the soil and water environment has been studied in Europe and the U.S. [62][63][64].…”

Section: Terpenes and Terpenoidsmentioning

confidence: 99%

Personal Care Products Are Only One of Many Exposure Routes of Natural Toxic Substances to Humans and the Environment

2018

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Abstract:The special issue "A Critical View on Natural Substances in Personal Care Products" is dedicated to addressing the multidisciplinary special challenges of natural ingredients in personal care products (PCP) and addresses also environmental exposure. In this perspective article, we argue that environmental exposure is probably not so much dominated by PCP use, but in many cases by direct emission from natural or anthropogenically managed vegetation, including agriculture. In support of this hypothesis, we provide examples of environmental fate and behaviour studies for compound classes that are either listed in the International Nomenclature of Cosmetics Ingredients (INCI) or have been discussed in a wider context of PCP applications and have been classified as potentially harmful to humans and the environment. Specifically, these include estrogenic isoflavones, the carcinogenic ptaquiloside and pyrrolizidine alkaloids, saponins, terpenes and terpenoids, such as artemisinin, and mycotoxins. Research gaps and challenges in the domains of human and environmental exposure assessment of natural products common to our currently rather separated research communities are highlighted.

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Loss of artemisinin produced by Artemisia annua L. to the soil environment

Cited by 25 publications

References 32 publications

Allelochemicals as Bioherbicides — Present and Perspectives

Allelochemicals as Bioherbicides — Present and Perspectives

Root regulation of artemisinin production in Artemisia annua: trichome and metabolite evidence

Personal Care Products Are Only One of Many Exposure Routes of Natural Toxic Substances to Humans and the Environment

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