2024
DOI: 10.1093/biolre/ioae137
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Loss of CCDC188 causes male infertility with defects in the sperm head–neck connection in mice

Yumiao Qiu,
Keisuke Shimada,
Kaito Yamamoto
et al.

Abstract: Acephalic spermatozoa syndrome (ASS) represents a rare genetic and reproductive disease, which is defined as semen composed of mostly headless spermatozoa. The connecting piece in the neck region, also known as the head-to-tail coupling apparatus (HTCA), plays a crucial role in the tight linkage between the sperm head and tail. Dysfunction of this structure can lead to separation of sperm heads and tails, and male infertility. Using the mouse as an experimental model, several proteins have been identified as a… Show more

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