1998
DOI: 10.1073/pnas.95.2.576
|View full text |Cite
|
Sign up to set email alerts
|

Loss of cell adhesion in Xenopus laevis embryos mediated by the cytoplasmic domain of XLerk, an erythropoietin-producing hepatocellular ligand

Abstract: The erythropoietin-producing hepatocellular (Eph) family of ligands and receptors has been implicated in the control of axon guidance and the segmental restriction of cells during embryonic development. In this report, we show that ectopic expression of XLerk, a Xenopus homologue of the murine Lerk-2 (ephrin-B1) transmembrane ligand, causes dissociation of Xenopus embryonic blastomeres by the mid-blastula transition. Moreover, a mutant that lacks the extracellular receptor binding domain can induce this phenot… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

1
40
0
1

Year Published

1998
1998
2017
2017

Publication Types

Select...
8
1

Relationship

1
8

Authors

Journals

citations
Cited by 79 publications
(42 citation statements)
references
References 48 publications
1
40
0
1
Order By: Relevance
“…The physiologic importance of ephrin-B signaling has been confirmed by multiple in vivo observations using signalingdeficient mutants of Ephs, or ephrins to show the requirement for signals transduced inside the cell by ephrin-Bs (20)(21)(22)(23)(24)(25)(26). At a cellular level, ephrin-B activity results in cytoskeletal rearrangements (11), inhibition of chemokine-induced migration (15), and generation of adhesive (27)(28)(29) or repulsive responses (11,(19)(20)(21)(30)(31)(32)(33)(34)(35).…”
Section: Introductionmentioning
confidence: 90%
See 1 more Smart Citation
“…The physiologic importance of ephrin-B signaling has been confirmed by multiple in vivo observations using signalingdeficient mutants of Ephs, or ephrins to show the requirement for signals transduced inside the cell by ephrin-Bs (20)(21)(22)(23)(24)(25)(26). At a cellular level, ephrin-B activity results in cytoskeletal rearrangements (11), inhibition of chemokine-induced migration (15), and generation of adhesive (27)(28)(29) or repulsive responses (11,(19)(20)(21)(30)(31)(32)(33)(34)(35).…”
Section: Introductionmentioning
confidence: 90%
“…At a cellular level, ephrin-B activity results in cytoskeletal rearrangements (11), inhibition of chemokine-induced migration (15), and generation of adhesive (27)(28)(29) or repulsive responses (11,(19)(20)(21)(30)(31)(32)(33)(34)(35).…”
Section: Introductionmentioning
confidence: 99%
“…Adhesion factors potentially regulated by Xlim5 include members of the cadherin and protocadherin families as well as Eph receptors and ephrin ligands, which have been implicated in mediating cell adhesion and migration (Holder and Klein, 1999). Interestingly, inhibition of NF-protocadherin, an ectodermspecific protocadherin (Bradley et al, 1998), or activation of Ephrin B1 signalling (Jones et al, 1998) both produce cell dissociation effects similar to Xlim5-EnR injection. This possibility is intriguing given the recent demonstration that Xlim1 regulated expression of PAPC (Hukriede et al, 2003).…”
Section: Role Of Xlim5 In Regulating Differential Adhesionmentioning
confidence: 99%
“…Loss of E-cadherin, the main cell adhesion molecule of early embryonic and adult epithelial cells, has been shown to aect the expression and subcellular localization of several Eph receptors and ephrins (Orsulic and Kemler, 2000;Zantek et al, 1999). Reciprocally, cadherin function may be regulated by Eph receptors and ephrins, since ectopic expression of ephrin-B1 or activated EphA4 in early Xenopus embryos disrupted cadherin dependent cell adhesion (Jones et al, 1998;Winning et al, 1996). The molecular mechanisms involved in this cross-regulation are still undetermined.…”
Section: Mechanisms Of Tumorigenesismentioning
confidence: 99%