Loss of cell adhesion molecule L1 like promotes tumor growth and metastasis in esophageal squamous cell carcinoma

Tang, Hong; Jiang, Lingxi; Zhu, Cailei; Liu, Raymond; Wu, Yufeng; Yan, Qian; Liu, Ming; Jia, Yong; Chen, Juan; Qin, Yanru; Lee, Victor; Luo, Suxia; Wang, Qiming; Guan, Xin Yuan

doi:10.1038/s41388-018-0648-7

Cited by 30 publications

(31 citation statements)

References 36 publications

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“…Soluble CHL1 or the remaining intracellular domain might then foster tumor cell migration and invasiveness. In accordance with this hypothesis, an association of decreased CHL1 expression with distant and lymph node metastases, as well as with reduced overall survival was reported for esophageal cancers [25]. The rate of CHL1 cleavage directly correlates with the amount of soluble CHL1 proteoforms, which are released into the environment and subsequently emitted into the blood stream.…”

Section: Discussionsupporting

confidence: 56%

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Expression and serum levels of the neural cell adhesion molecule L1-like protein (CHL1) in gastrointestinal stroma tumors (GIST) and its prognostic power

et al. 2020

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Introduction: Diagnosis of gastrointestinal stroma tumors (GIST) is based on the histological evaluation of tissue specimens. Reliable systemic biomarkers are lacking. We investigated the local expression of the neural cell adhesion molecule L1-like protein (CHL1) in GIST and determined whether soluble CHL1 proteoforms could serve as systemic biomarkers. Material and Methods: Expression of CHL1 was analyzed in primary tumor specimens and metastases. 58 GIST specimens were immunohistochemically stained for CHL1 on a tissue microarray (TMA). Systemic CHL1 levels were measured in sera derived from 102 GIST patients and 91 healthy controls by ELISA. Results were statistically correlated with clinicopathological parameters. Results: CHL1 expression was detected in GIST specimens. Reduced tissue expression was significantly associated with advanced UICC stages (p = 0.036) and unfavorable tumor localization (p = 0.001). CHL1 serum levels are significantly elevated in GIST patients (p < 0.010). Elevated CHL1 levels were significantly associated with larger tumors (p = 0.023), advanced UICC stage (p = 0.021), and an increased Fletcher score (p = 0.041). Moreover, patients with a higher CHL1 serum levels displayed a significantly shortened recurrence free survival independent of other clinicopathological variables. Conclusion: Local CHL1 expression and serum CHL1 levels show a reverse prognostic behavior, highlighting the relevance of proteolytic shedding of the molecule. The results of the study indicate a potential role of serum CHL1 as a diagnostic and prognostic marker in GIST.

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Section: Discussionsupporting

confidence: 56%

“…Furthermore, CHL1 expression in esophageal and lung cancer is significantly correlated with a favorable outcome [23,24]. In addition, a functional role as a tumor suppressor in the Akt pathway in esophageal cancer was found [25]. Another recent study also demonstrated a tumor suppressive function of CHL1 in neuroblastoma [26].…”

Section: Introductionmentioning

confidence: 96%

Expression and serum levels of the neural cell adhesion molecule L1-like protein (CHL1) in gastrointestinal stroma tumors (GIST) and its prognostic power

et al. 2020

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“…promote human cervical cancer cells invasion and migration through negative regulation of CHL1 (Chu et al 2014, Long et al 2012). In the majority tumors, CHL1 is a potential tumor suppressor gene, whose silencing is attribute to tumor growth, invasion and metastasis (He et al 2013, Martin-Sanchez et al 2017, Morellini et al 2007, Tang et al 2019, Zhu et al 2014).…”

Section: Discussionmentioning

confidence: 99%

“…Recently, research have been showed that CHL1 could inhibits Akt activity (Ognibene et al 2018, Tang et al 2019. To evaluate whether CHL1 mediated the chemoresistance via Akt pathway in NSCLC, we detected the expression of Akt in CHL1 silenced and overexpressed cells.…”

Section: Chl1 Mediates Chemosensitivity Via Inhibition Akt Activitymentioning

confidence: 99%

“…In esophageal squamous cell carcinoma (ESCC), CHL1 down-regulation was associated with invasion, lymph-node metastasis, and poor overall survival (Tang et al 2019). The expression of CHL1 was downregulated by hypermethylation in human breast cancer, and it negative expression was contribute to breast tumorigenesis and progression (He et al 2013, Martin-Sanchez et al 2017).…”

Section: Introductionmentioning

confidence: 99%

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Close homologue of L1 sensitizes lung cancer cells to cisplatin and paclitaxel via inhibition Akt pathway

Liu

et al. 2019

Preprint

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Drug resistance is a serious promble during chemotherapy in lung cancer, which may lead to tumor relapse and further progression. CHL1 was a tumor suppressor in most malignancies, and it was found downregulated in NSCLC cisplatin-resistant cells H460. Thus, in this study, we investigated the role and mechanism of chemoresistance by CHL1 in lung cancer. Human lung adenocarcinoma cell lines A549 and its cisplatin resistant cells (A549/DDP) and paclitaxel resistant cells (A549/PTX) were applied in this research. CHL1 was found obvious downregulation in A549/DDP and A549/PTX cells versus A549 cells. Suppression of CHL1 in A549 cells, promoted cell survival rate and clone formation, decreased cell apoptosis when treated with or without DDP and PTX, respectively. While excessive CHL1 expression in A549/DDP and A549/PTX cells, the results were opposite. Moreover, CHL1 knockdown mediating chemoresistance was reversed by Akt inhibitor SC66 in A549 cells. In summary, overexpression of CHL1 reversed chemoresistance to cisplatin and PTX via suppressing Akt pathway in lung cancer, it was suggested that CHL1 maybe as a potential target for overcome chemoresistance in lung cancer.

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Loss of STARD13 contributes to aggressive phenotype transformation and poor prognosis in papillary thyroid carcinoma

Zeng

Liang

et al. 2023

Endocrine

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Loss of cell adhesion molecule L1 like promotes tumor growth and metastasis in esophageal squamous cell carcinoma

Cited by 30 publications

References 36 publications

Expression and serum levels of the neural cell adhesion molecule L1-like protein (CHL1) in gastrointestinal stroma tumors (GIST) and its prognostic power

Expression and serum levels of the neural cell adhesion molecule L1-like protein (CHL1) in gastrointestinal stroma tumors (GIST) and its prognostic power

Close homologue of L1 sensitizes lung cancer cells to cisplatin and paclitaxel via inhibition Akt pathway

Loss of STARD13 contributes to aggressive phenotype transformation and poor prognosis in papillary thyroid carcinoma

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