2003
DOI: 10.1073/pnas.1432873100
|View full text |Cite
|
Sign up to set email alerts
|

Loss of chloride channel ClC-5 impairs endocytosis by defective trafficking of megalin and cubilin in kidney proximal tubules

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3

Citation Types

18
314
2
2

Year Published

2005
2005
2017
2017

Publication Types

Select...
4
4

Relationship

0
8

Authors

Journals

citations
Cited by 293 publications
(336 citation statements)
references
References 46 publications
18
314
2
2
Order By: Relevance
“…We assume that the internalized NaPi-II was degraded after the repeated administration of His-sRAP, although the reduction in the amount of NaPi-II protein was not obvious after a single injection. As previously reported, ClC-5-deficient mice exhibit secondary dysfunction of megalin and a defect in trafficking of NaPi-II (17,18). The findings in our model using His-sRAP together with the observation in ClC-5-deficient mice indicate the involvement of megalin in renal phosphate uptake.…”
Section: Discussionsupporting
confidence: 88%
See 1 more Smart Citation
“…We assume that the internalized NaPi-II was degraded after the repeated administration of His-sRAP, although the reduction in the amount of NaPi-II protein was not obvious after a single injection. As previously reported, ClC-5-deficient mice exhibit secondary dysfunction of megalin and a defect in trafficking of NaPi-II (17,18). The findings in our model using His-sRAP together with the observation in ClC-5-deficient mice indicate the involvement of megalin in renal phosphate uptake.…”
Section: Discussionsupporting
confidence: 88%
“…Although it is still not clear which human disease is caused directly by a defect in megalin, some diseases, including Dent's disease and some forms of renal Fanconi syndrome, are reported to be associated with secondary malfunction of megalin (15,16). Reduced apical expression of megalin in the proximal tubules, as well as reduced levels of megalin detected in urine, was demonstrated in a mouse model of Dent's disease (17,18). In addition, some medicines such as antibiotics (aminoglycosides) and anticancer drugs exert a nephrotoxic effect and cause malfunction of renal tubular cells (19,20).…”
mentioning
confidence: 99%
“…This pattern of independent protein regulation of megalin and cubilin has been demonstrated in the same animal model (Christensen et al. 2003). Additional experiments are necessary to understand the differential regulation of megalin and cubilin protein and mRNA expression.…”
Section: Discussionmentioning
confidence: 99%
“…Also, this increase in urinary excretion of transferrin was observed in ClC‐5 KO mice (Christensen et al. 2003). …”
Section: Discussionmentioning
confidence: 99%
“…Another possible role played by ClC-5 is in mediating the protein-protein interactions that are involved in the assembly of the endocytic complex (6). This hypothesis is supported by data from the proximal tubules of ClC-5 knock-out mice and patients with Dent's disease where megalin is down-regulated and the v-H ϩ -ATPase is mistrafficked to the basolateral domain (18,19). It is also clear that albumin uptake involves actin cytoskeleton acting as an anchoring point for the endocytic complex (20 -22), because disruption of the cytoskeleton abolishes albumin uptake (21,23).…”
mentioning
confidence: 83%