2000
DOI: 10.1016/s1097-2765(00)00030-7
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Loss of E2F4 Activity Leads to Abnormal Development of Multiple Cellular Lineages

Abstract: We have generated mice deficient in E2F4 activity, the major form of E2F in many cell types. Analysis of newborn pups deficient in E2F4 revealed abnormalities in hematopoietic lineage development as well as defects in the development of the gut epithelium. Specifically, we observed a deficiency of various mature hematopoietic cell types together with an increased number of immature cells in several lineages. This was associated with an increased frequency of apoptotic cells. We also found a substantial reducti… Show more

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Cited by 152 publications
(163 citation statements)
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“…Among these, E2F4 is found at high concentrations in hemopoietic cells (15). Overexpression of E2F4 promotes terminal differentiation of cells in vitro (16), whereas E2F4-deficient animals show reduced neonatal viability, with very few animals surviving to adulthood (15,17).…”
Section: E2f4 Modulates Differentiation and Gene Expression In Hemopomentioning
confidence: 99%
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“…Among these, E2F4 is found at high concentrations in hemopoietic cells (15). Overexpression of E2F4 promotes terminal differentiation of cells in vitro (16), whereas E2F4-deficient animals show reduced neonatal viability, with very few animals surviving to adulthood (15,17).…”
Section: E2f4 Modulates Differentiation and Gene Expression In Hemopomentioning
confidence: 99%
“…Among these, E2F4 is found at high concentrations in hemopoietic cells (15). Overexpression of E2F4 promotes terminal differentiation of cells in vitro (16), whereas E2F4-deficient animals show reduced neonatal viability, with very few animals surviving to adulthood (15,17). These animals died due to opportunistic infections and anemia, but they were also smaller than either heterozygous or wild-type (WT) littermates (15,17).…”
Section: E2f4 Modulates Differentiation and Gene Expression In Hemopomentioning
confidence: 99%
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