2022
DOI: 10.3389/fonc.2022.815737
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Loss of Frizzled 9 in Lung Cells Alters Epithelial Phenotype and Promotes Premalignant Lesion Development

Abstract: The transmembrane receptor Frizzled 9 (FZD9) is important for fetal neurologic and bone development through both canonical and non-canonical WNT/FZD signaling. In the adult lung, however, Fzd9 helps to maintain a normal epithelium by signaling through peroxisome proliferator activated receptor γ (PPARγ). The effect of FZD9 loss on normal lung epithelial cells and regulators of its expression in the lung are unknown. We knocked down FZD9 in human bronchial epithelial cell (HBEC) lines and found that downstream … Show more

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“…Frizzled9 (Fzd9) is a G-protein-coupled transmembrane receptor that is commonly expressed in brain, testis, skeletal muscle, and kidney tissue [ 15 ]. It is also the Wnt receptor of the Frizzled family, which positively regulates bone reconstruction through an atypical Wnt pathway without involving B-catenin-dependent signal transduction [ 16 ].…”
Section: Introductionmentioning
confidence: 99%
“…Frizzled9 (Fzd9) is a G-protein-coupled transmembrane receptor that is commonly expressed in brain, testis, skeletal muscle, and kidney tissue [ 15 ]. It is also the Wnt receptor of the Frizzled family, which positively regulates bone reconstruction through an atypical Wnt pathway without involving B-catenin-dependent signal transduction [ 16 ].…”
Section: Introductionmentioning
confidence: 99%