Loss of function ofAtrxleads to activation of alternative lengthening of telomeres in a primary mouse model of sarcoma
Matthew Pierpoint,
Warren Floyd,
Amy J. Wisdom
et al.
Abstract:The development of a telomere maintenance mechanism is essential for immortalization in human cancer. While most cancers elongate their telomeres by expression of telomerase, 10-15% of human cancers use a pathway known as alternative lengthening of telomeres (ALT). In this work, we developed a genetically engineered primary mouse model of sarcoma in CAST/EiJ mice which displays multiple molecular features of ALT activation after CRISPR/Cas9 introduction of oncogenicKrasG12Dand loss of function mutations ofTrp5… Show more
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