Loss of heterozigosity of lp chromosome in neuroblastoma

Peculiar allelotype associated with susceptibility to neuroblastoma

“…T h e frequent involvement of locus DIS94 emphasized that the putative NB suppressor gene is near or within chromosome region 1~36.33. Four cases (340, 619, 321, and 583) showed a larger deletion encompassing the lp33-lp36 region (Table 1) LOH for l p loci has been reported with a frequency ranging between 25 and 89% (Fong et al, 1989;Weith et al, 1989;Hunt and Tereba, 1990;Takayama et al, 1992;Valenti et al, 1993;Takeda et al, 1994;Caron, 1995). T h e great variability of LOH incidence may be ascribed to differences in the techniques or the probes used or to differences in the populations studied.…”