Loss of heterozygosity at chromosome 9q22-31 is a frequent and early event in ovarian tumors

The anaplastic lymphoma kinase as an oncogene in solid tumors

“…The prevalence of LOH was 50% for BCC, and 27.27% for OC. In literature the prevalence of LOH in BCCs is between 35 and 75% (40,22,41,42,26) and 70% for ovarian tumors, both benign and malignant (30). Our data is comparable with published data for BCC, but is significantly lower for OC.…”

“…Unlike healthy epithelial ovarian tissue, OC shows increased protein expression of the members of the pathway (29). Also, ovarian tumors often show LOH of the PTCH1 gene (30). Benign tumors of the ovary also show promoter hypermethylation (31), while OC do not (32).…”

The Hedgehog signaling pathway in ovarian teratoma is stimulated by Sonic Hedgehog which induces internalization of Patched

“…Involvement of Hh-Gli signaling in ovarian carcinogenesis has been demonstrated (14,15), but its detailed role in germ cell tumorigenesis has yet to be thoroughly examined. We used ovarian dermoids as they show characteristics of tumors and developmental malformations, and Hh-Gli signaling is involved in both processes.…”

“…Also, ovarian carcinomas frequently show loss of one allele of the PTCH1 gene (15), and ovarian teratomas show increased methylation of the PTCH1 promoter (16).…”

The elusive multiple self-healing squamous epithelioma (MSSE) gene: further mapping, analysis of candidates, and loss of heterozygosity

“…Up to 65% of cutaneous squamous cell carcinoma (SCC) have LOH at a region of 9q22.3 but no mutations in PTCH or XPA were found, suggesting the existence of another TSG in this region important for sporadic SCC The MSSE skin tumour suppressor gene S Bose et al development (Ahmadian et al, 1998). Also TSGs for other cancers are suspected to reside between 9q22-q31 (Byrom et al, 2004). It is possible that the MSSE TSG may play a role in these other sporadic tumours.…”