Loss of heterozygosity on chromosome 14 in primary nasopharyngeal carcinoma

Monochromosome transfer provides functional evidence for growth‐suppressive genes on chromosome 14 in nasopharyngeal carcinoma

“…Multiple genetic alterations on chromosome 14 are believed to be involved in the pathogenesis of NPC. In this cancer, the deleted regions were found along almost the entire long arm of chromosome 14 in primary samples (Cheng et al, 1997;Mutirangura et al, 1998;Lo et al, 2000;Lung et al, 2001). It is thus necessary to narrow down critical regions of loss for the purpose of identifying candidate genes.…”

“…Genetic loss of chromosome 14 was also detected by comparative genomic hybridization (CGH) and loss of heterozygosity (LOH) studies in nasopharyngeal carcinoma (NPC). Multiple and extensive deletions of chromosome 14 were observed in NPC primary samples (Cheng et al, 1997;Mutirangura et al, 1997Mutirangura et al, , 1998Chen et al, 1999;Hui et al, 1999;Lo et al, 2000;Fang et al, 2001;Lung et al, 2001). These deleted regions may contain putative TSGs, which are required for neoplastic transformation of normal cells.…”

Chromosomal aberrations in nasopharyngeal carcinoma analyzed by comparative genomic hybridization

“…Previous LOH studies have identified gene deletions from chromosome arms 3p, 9p, 11q, and 14q [Huang et al, 1994;Hu et al, 1996;Hui et al, 1996;Cheng et al, 1997]. These alterations were also revealed by our CGH analysis, suggesting the 2p22,2q37,9q34,11p15,11q13,12p13,12q24,17p13,17q,19p,19q,9q34,11q13,16p11,p13,q25,19p,19q,20q11 1q32,6p,7p,11p15,12p13,18p11 fidelity of using CGH in detecting chromosome changes.…”

Two distinct regions of deletion on chromosome 13q in primary nasopharyngeal carcinoma

“…On the other hand, there is evidence that inactivation of the tumour-suppressor gene p16, by homozygous deletion or hypermethylation, is involved in the development of this disease . Furthermore, loss-of-heterozygosity (LOH) studies have shown frequent deletions on chromosomes 3p, 9p, 11q, and 14q, suggesting that tumour-suppressor genes located on these regions may play important roles in NPC tumorigenesis Huang et al, 1994;Hui et al, 1996;Cheng et al, 1997).…”