2013
DOI: 10.1118/1.4795131
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Loss of local control due to tumor displacement as a function of margin size, dose–response slope, and number of fractions

Abstract: Margins depend on the number of fractions and γ50 in addition to Σ and σ. Dose conformity should also be considered since the required margin increases with increasing dose conformity. Ideally margins should be anisotropic and individualized, taking into account γ50, number of fractions, and the dose distribution, as well as estimates of Σ and σ. No single "recipe" can adequately account for all these variables.

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Cited by 12 publications
(21 citation statements)
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“…A significant drop in target dose is seen compared to the physical case at 2 Gy, while good correspondence is seen at 8 Gy per fraction. For physical dose distributions alone (figure 6(a)), these results are comparable to previous publications (Selvaraj et al 2013). Geometric uncertainties have a greater impact in hypo-fractionated treatments, due to larger risks of geometric miss and subsequent under-dosing.…”
Section: Patient Datasupporting
confidence: 80%
See 3 more Smart Citations
“…A significant drop in target dose is seen compared to the physical case at 2 Gy, while good correspondence is seen at 8 Gy per fraction. For physical dose distributions alone (figure 6(a)), these results are comparable to previous publications (Selvaraj et al 2013). Geometric uncertainties have a greater impact in hypo-fractionated treatments, due to larger risks of geometric miss and subsequent under-dosing.…”
Section: Patient Datasupporting
confidence: 80%
“…As in previous radiotherapy margin studies (Van Herk et al 2000, van Herk 2004, Selvaraj et al 2013, the irradiation of spherical CTVs was modelled. Dose deliveries are prescribed to a PTV, which is defined as the CTV plus a uniform margin.…”
Section: Treatment Scenario and Dose Distributionsmentioning
confidence: 99%
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“…(1,1) Australas Phys Eng Sci Med as described in Selvaraj et al [31] is used for simulating the effect of geometric uncertainties on TCP with an exponentially decreasing clonogen density in the GTV-CTV region. The enhanced 'Marsden' TCP model [32] was used for the TCP calculations with a = 0.3 Gy -1 , a/b = 10 Gy and r a = 0.07 Gy -1 .…”
Section: Slopementioning
confidence: 99%