Loss of lysophosphatidic acid receptor-3 enhances cell migration in rat lung tumor cells

Diverse effects of LPA4, LPA5 and LPA6 on the activation of tumor progression in pancreatic cancer cells

“…Moreover, mutated LPA 1 increased the cell motile and invasive activities, matrix metalloproteinase (MMP) activation and angiogenesis in neuroblastoma cells [5,6]. In contrast, the cell motile activity was suppressed by LPA 3 in lung cancer cells [7].…”

“…For cell invasion assay, the filters were coated with Matrigel (12.5 mg/filter) (BD Falcon) and dried for at least 1 day. Cells were seeded into the filter at 1 Â 10 5 cells and incubated for 20 h[4,5,7].…”

Expression of Lysophosphatidic Acid Receptors and Local Invasiveness and Metastasis in Chinese Pancreatic Cancers

“…There is inconsistency with respect to its expression in cancer. For instance, it is overexpressed in ovarian cancer and ovarian cancer cell lines, but overexpression was not observed in other human cancer types 25 .…”

Lysophosphatidic acid (LPA) and endothelial differentiation gene (Edg) receptors in human pancreatic cancer

“…There is also suggestion that loss of LPA3 enhances LPA1-mediated tumor cell migration. Thus a generalized role for LPA3 in cancer remains to be fully determined although this receptor is capable of eliciting many cellular responses to LPA when exogenously overexpressed in mammalian cells [30].…”