Loss of microbiota depletes cross-reactive Foxp3⁺ Tregs leading to selective immunopathologies

Abstract

The 'Hygiene hypothesis', a cornerstone model to account for the role of exogenous pathogens and later of endogenous microbiota in immune disorders, is currently presumed to operate at the innate immunity and metabolite levels to properly 'educate' the immune system. Doing so however fails to satisfactorily account for the antigen-specific nature of such disorders.SPIRAL is a novel interpretive framework that resolves this dilemma. It represents the periodic