Loss of neutrophil polarization in colon carcinoma liver metastases of mice with an inducible, liver-specific IGF-I deficiency

Rayes, Roni F.; Milette, Simon; Fernández, María Celia; Ham, Boram; Wang, Ni; Perrino, Stephanie; Yakar, Shoshana; Brodt, Pnina

doi:10.18632/oncotarget.24593

Cited by 15 publications

(14 citation statements)

References 60 publications

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“…In mice subjected to IGF-1 deficiency three weeks but not two days prior to the inoculation of CRC cells, infiltrated neutrophils in the liver did not show characteristics of tumor-promoting phenotypes, although the number of neutrophils was increased. They suggested that sustained IGF-1 deficiency is necessary to alter the neutrophil phenotype [85].…”

Section: Tans In Animal Model For Crc Liver Metastasismentioning

confidence: 99%

The Role of Tumor-Associated Neutrophils in Colorectal Cancer

Mizuno

Kawada

Itatani

et al. 2019

IJMS

244

219

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Colorectal cancer (CRC) is one of the most common causes of cancer deaths worldwide and the number of CRC patients is increasing progressively. Despite the improvement of the surgical techniques and chemotherapy, we have not completely overcome this disease yet due to the metastases. Therefore, understanding the mechanisms through which metastasis occurs is important for overcoming CRC. Normal host cells in the tumor microenvironment, such as macrophages and fibroblasts, have been reported to promote the growth of CRCs. Although neutrophils were originally considered to have defensive functions against tumor cells, it has been revealed that some populations of neutrophils, called as tumor-associated neutrophils (TANs), have tumor-supportive functions. The plasticity between tumor-suppressive and -supportive neutrophils are regulated by transforming growth factor (TGF)-β and Interferon-β signaling. Some studies have demonstrated that TANs promote the spread of cancer cells to distant organs. TANs contribute to the tumor invasion and angiogenesis through the production of matrix metalloproteinase-9 (MMP9), vascular endothelial growth factor (VEGF), and hepatocyte growth factor (HGF) in the primary and metastatic sites. Neutrophils also promotes tumor cell dissemination by capturing circulating tumor cells using neutrophil extracellular traps and promote their migration to distant sites. The neutrophil-to-lymphocyte ratio is a well-defined predictive marker for CRC patients. In this review, we highlight the molecular signaling between TANs and CRC cells and the possibility of TANs as a potential target for cancer therapy.

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Section: Tans In Animal Model For Crc Liver Metastasismentioning

confidence: 99%

The Role of Tumor-Associated Neutrophils in Colorectal Cancer

Mizuno

Kawada

Itatani

et al. 2019

IJMS

244

219

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“…Moreover, liver inflammation induced by obesity was abrogated in liver specific IGF-I deficient mice leading to a significant reduction of in liver metastasis [ 156 ]. Furthermore, IGF-1 promotes neutrophil polarization to a tumor promoting phenotype and the induction of a prometastatic microenvironment in the liver [ 157 ].…”

Section: Mechanisms Linking Adipose Tissue To the Metastatic Cascamentioning

confidence: 99%

Obesity and Cancer Metastasis: Molecular and Translational Perspectives

Annett

Moore

Robson

2020

Cancers

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Obesity is a modern health problem that has reached pandemic proportions. It is an established risk factor for carcinogenesis, however, evidence for the contribution of adipose tissue to the metastatic behavior of tumors is also mounting. Over 90% of cancer mortality is attributed to metastasis and metastatic tumor cells must communicate with their microenvironment for survival. Many of the characteristics observed in obese adipose tissue strongly mirror the tumor microenvironment. Thus in the case of prostate, pancreatic and breast cancer and esophageal adenocarcinoma, which are all located in close anatomical proximity to an adipose tissue depot, the adjacent fat provides an ideal microenvironment to enhance tumor growth, progression and metastasis. Adipocytes provide adipokines, fatty acids and other soluble factors to tumor cells whilst immune cells infiltrate the tumor microenvironment. In addition, there are emerging studies on the role of the extracellular vesicles secreted from adipose tissue, and the extracellular matrix itself, as drivers of obesity-induced metastasis. In the present review, we discuss the major mechanisms responsible for the obesity–metastatic link. Furthermore, understanding these complex mechanisms will provide novel therapies to halt the tumor–adipose tissue crosstalk with the ultimate aim of inhibiting tumor progression and metastatic growth.

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“…Insulin-like growth factor 1 (IGF-1) has been shown to induce metastasis and the signaling pathways involved in the promotion of EMT. Therefore, depletion of IGF-1 and prevented polarization of TAN to their pro-metastatic (N2) phenotype [25, 26].…”

Section: Cellular Componentsmentioning

confidence: 99%

The role of liver microenvironment in hepatic metastasis

Williamson

Sultanpuram

Sendi

2019

Clinical & Translational Med

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Metastasis is still poorly understood and thus further research must be conducted to provide insight into the driving factors. Novel research has revealed the significance of the microenvironment in the delegation of metastasis, expanding the field of cancer metastasis to cells and cell environments surrounding the migrated tumor cells. Research on hepatic metastasis is an ever-growing domain of this field, as several primary tumors can metastasize to the liver. The two features within the liver that promote metastasis—cellular and acellular—are found in the current interpretation of liver microenvironment. Novel findings of both are included in this review. Different hypotheses detailing the methods by which metastasis can occur must be included to understand the significance of the microenvironment, as well as a brief overview of the methods that can be used during research. This review aims to highlight the importance of liver microenvironment on the development or potential regression of hepatic metastasis through discussing both acellular and cellular components of liver microenvironment and their interaction with metastasis.

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Loss of neutrophil polarization in colon carcinoma liver metastases of mice with an inducible, liver-specific IGF-I deficiency

Cited by 15 publications

References 60 publications

The Role of Tumor-Associated Neutrophils in Colorectal Cancer

The Role of Tumor-Associated Neutrophils in Colorectal Cancer

Obesity and Cancer Metastasis: Molecular and Translational Perspectives

The role of liver microenvironment in hepatic metastasis

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