2008
DOI: 10.1182/blood.v112.11.1663.1663
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Loss of p53 Is a Marker of Progression in Plasma Cell Neoplasias and Is a Negative Prognostic Factor in Relapsed Disease.

Abstract: Table 1. Samples to p53 deletions p 53 deletion FISH aCGH FISH and aCGH MGUS 142 - - SMM 108 - - Newly diagnosed MM - 182 - Relapsed/refractory MM 62 156 19 HMCLs - 48 - Total 312 386 19 Background: Inactivation of p53 by mutation or allelic loss is a rare event in multiple myeloma (MM) at the time of disease diagnosis and believed to be more common in the late stages of the disease. Here we defined the prevalence of p53 deletions in monoclonal gammopathy of undetermined significa… Show more

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“…The number of prior lines of therapy was previously reported as 1 of the major factors to predict survival [12]. This is likely a surrogate marker for the presence of chemoresistant disease or the persistence of subclinical cumulative toxicity from prior therapies but also could reflect an increase of acquired genetic aberrations such as p53 deletion [25].…”
Section: Discussionmentioning
confidence: 97%
“…The number of prior lines of therapy was previously reported as 1 of the major factors to predict survival [12]. This is likely a surrogate marker for the presence of chemoresistant disease or the persistence of subclinical cumulative toxicity from prior therapies but also could reflect an increase of acquired genetic aberrations such as p53 deletion [25].…”
Section: Discussionmentioning
confidence: 97%
“…On the other hand, it is unclear why plasma cells escape from the bone marrow and become PCL. Emergence of TP53 deletion/mutations denotes progression genetic events in MM (22). The prevalence of TP53 deletion detected either by FISH or by array CGH is approximately 80% in PCL, and this genetic abnormality is thought to be responsible for the presence of extramedullary disease in MM.…”
Section: Discussionmentioning
confidence: 99%