2003
DOI: 10.1002/cncr.11847
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Loss of surface and cyst epithelial basement membranes and preneoplastic morphologic changes in prophylactic oophorectomies

Abstract: BACKGROUND The authors suggested that the loss of collagen IV and laminin‐containing basement membrane and the loss of Disabled‐2 (Dab2) expression were two critical events associated with morphologic dysplastic changes of the ovarian surface epithelium as a step in tumorigenicity. Both the basement membrane and Dab2, a candidate tumor suppressor of ovarian carcinoma, were involved in epithelial cell surface positioning and organization. The authors speculated that the purging of the basement membrane may be s… Show more

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Cited by 62 publications
(57 citation statements)
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References 69 publications
(143 reference statements)
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“…Although increased COX-2 expression was often observed in preneoplastic ovarian surface epithelium (Roland et al, 2003), the direct stimulator of COX-2 expression was not yet established. Reproductive hormones and local mediators of ovulation are likely candidates to regulate COX-2 expression.…”
Section: Cox-2 Expression In Primary and Nontumorigeneic Ovarian Surfmentioning
confidence: 98%
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“…Although increased COX-2 expression was often observed in preneoplastic ovarian surface epithelium (Roland et al, 2003), the direct stimulator of COX-2 expression was not yet established. Reproductive hormones and local mediators of ovulation are likely candidates to regulate COX-2 expression.…”
Section: Cox-2 Expression In Primary and Nontumorigeneic Ovarian Surfmentioning
confidence: 98%
“…In contrast to cancers of other organ sites, ovarian tumors and most ovarian cancer cell lines are negative for COX-2 expression (Gupta et al, 2003;Roland et al, 2003). We analysed the expression of COX-2 and its regulation in five ovarian cancer cell lines: A2780, OVCAR4, OVCAR8, and OVCAR10 are COX-2 negative, and OVCAR5 is positive for COX-2.…”
Section: Lack Of Cox-2 Induction By Tnf-a In Ovarian Cancer Cellsmentioning
confidence: 99%
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“…While several studies have failed to detect such difference at the histopathological level, 11,[27][28][29][30] others have detected such differences between these two different groups. 10,12,[31][32][33][34][35][36][37] In addition, human ovarian-surface epithelial (HOSE) cells from patients with a family history of breast or ovarian cancer show increased CA-125 expression 34 and more stable expression of the Met receptor for hepatocyte growth factor (HGF) than do HOSE cells from patients without such a history. 38 Transformation of HOSE cells with the SV40 T/t antigen led to increased telomere instability and reduced growth potential in cells from patients with a family history of breast or ovarian cancer, indicating that those cells were closed to replicative senescence.…”
Section: Discussionmentioning
confidence: 99%