Loss of the nutrient receptor Tas1R3 reduces atherosclerotic plaque accumulation and hepatic steatosis in ApoE−/− mice

Shojaat, Shayla; Engman, Samuel; Hofferber, Jason; Keomanivong, F. E.; Wauson, Eric M.

doi:10.1007/s13105-020-00768-8

Cited by 4 publications

(2 citation statements)

References 48 publications

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“…The sweet taste receptors (STR), including taste receptor type 1 membrane 2 (T1R2) and taste receptor type 1 membrane 3 (T1R3) are expressed in numerous extra-gustatory tissues ( 11 ), playing an important role in energy balance, glucose homeostasis ( 12 ), and lipid metabolism ( 13 ). It was known that STR are also expressed in liver ( 14 , 15 ), and loss of T1R3 reduces atherosclerotic plaque accumulation and hepatic steatosis in ApoE knockout mice ( 16 ). Although STR can be activated by sucralose and further triggering of physiological responses, the effects of sucralose on hepatic lipid accumulation were still obscure.…”

Section: Introductionmentioning

confidence: 99%

Sucralose, a Non-nutritive Artificial Sweetener Exacerbates High Fat Diet-Induced Hepatic Steatosis Through Taste Receptor Type 1 Member 3

Lin

Pai

et al. 2022

Front. Nutr.

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Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease globally, and it is strongly associated with obesity. To combat obesity, artificial sweeteners are often used to replace natural sugars, and sucralose is one of the most extensively used sweeteners. It was known that sucralose exerted effects on lipid metabolism dysregulation, and hepatic inflammation; however, the effects of sucralose on hepatic steatosis were still obscure. In this study, we found that supplements of sucralose enhanced high-fat-diet (HFD)-induced hepatic steatosis. In addition, treatment of sucralose increased reactive oxygen species (ROS) generation and induced endoplasmic reticulum (ER) stress in HepG2 cells. Pretreatment of ROS or ER stress inhibitors reversed the effects of sucralose on lipogenesis. Furthermore, pretreatment of taste receptor type 1 membrane 3 (T1R3) inhibitor or T1R3 knockdown reversed sucralose-induced lipogenesis in HepG2 cells. Taken together, sucralose might activate T1R3 to generate ROS and promote ER stress and lipogenesis, and further accelerate to the development of hepatic steatosis.

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Section: Introductionmentioning

confidence: 99%

Sucralose, a Non-nutritive Artificial Sweetener Exacerbates High Fat Diet-Induced Hepatic Steatosis Through Taste Receptor Type 1 Member 3

Lin

Pai

et al. 2022

Front. Nutr.

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“…Sci. 2021 4 (1) 59-67 61 out, compared to ApoE-/-TAS1R3+/+ mice (Shojaat et al, 2020). Even though these receptors have been associated with various metabolic disorders, TAS1R3 expression was not modified in the jejunal tissue of women with obesity or metabolic syndrome (Bertran et al, 2021).…”

Section: Reviews In Biological Andmentioning

confidence: 97%

TAS1 receptors. An overview of their functions, expression and genetic variations

Opriță¹,

Babeș²,

Domocoș³

2022

Rev. Biol. Biomed. Sci.

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Heteromeric G protein-coupled receptors are essential in taste transduction, a characteristic important for vertebrates. Type 1 taste receptors mediate sweet and umami sensing via two heterodimers: TAS1R2/TAS1R2 and TAS1R1/TAS1R3. Evidently, these heterodimers are expressed in taste buds, but also in several other tissues like the gastrointestinal tract, bone, pancreas and bladder. Because of its role in transducing the sweet taste, there have been plenty of investigations regarding genetic variations associated with obesity or dental caries.

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Anti-atherosclerosis effect of nobiletin via PINK1/Parkin-mediated mitophagy and NLRP3 inflammasome signaling pathway

Deng

Yang

et al. 2023

Journal of Functional Foods

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Loss of the nutrient receptor Tas1R3 reduces atherosclerotic plaque accumulation and hepatic steatosis in ApoE−/− mice

Cited by 4 publications

References 48 publications

Sucralose, a Non-nutritive Artificial Sweetener Exacerbates High Fat Diet-Induced Hepatic Steatosis Through Taste Receptor Type 1 Member 3

Sucralose, a Non-nutritive Artificial Sweetener Exacerbates High Fat Diet-Induced Hepatic Steatosis Through Taste Receptor Type 1 Member 3

TAS1 receptors. An overview of their functions, expression and genetic variations

Anti-atherosclerosis effect of nobiletin via PINK1/Parkin-mediated mitophagy and NLRP3 inflammasome signaling pathway

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