2007
DOI: 10.1038/sj.onc.1210450
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Loss of the retinoblastoma tumor suppressor: differential action on transcriptional programs related to cell cycle control and immune function

Abstract: Functional inactivation of the retinoblastoma tumor suppressor gene product (RB) is a common event in human cancers. Classically, RB functions to constrain cellular proliferation, and loss of RB is proposed to facilitate the hyperplastic proliferation associated with tumorigenesis. To understand the repertoire of regulatory processes governed by RB, two models of RB loss were utilized to perform microarray analysis. In murine embryonic fibroblasts harboring germline loss of RB, there was a striking deregulatio… Show more

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Cited by 72 publications
(72 citation statements)
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“…Cyclin A was exclusively expressed in crypts in normal mice. Its expression has been shown to be regulated by pRb (13,20,21). However, in small intestine, its expression seemed unaffected by any pocket protein studied.…”
Section: Vcϩrb(f/f) Mice Small Intestine Show Compensatory Expressionmentioning
confidence: 91%
“…Cyclin A was exclusively expressed in crypts in normal mice. Its expression has been shown to be regulated by pRb (13,20,21). However, in small intestine, its expression seemed unaffected by any pocket protein studied.…”
Section: Vcϩrb(f/f) Mice Small Intestine Show Compensatory Expressionmentioning
confidence: 91%
“…To demonstrate that altered regulation general, the loss of RB function is associated with the deregulation of the transcription of coding genes that contribute to diverse biological processes. 9,31 In particular, RB modulates the expression of genes involved in DNA replication and can correspondingly deregulate multiple facets of replication control. While MCM7 has a key role in replication control, 32,33 it also harbors the mir106b cluster that is disease-relevant and encodes three miRNA species that target multiple disease-relevant coding genes (e.g., PTEN and p21…”
Section: Resultsmentioning
confidence: 99%
“…Proximally, the RB protein functions as a transcriptional repressor of the E2F family of transcription factors (Nevins, 2001;Dynlacht, 2004, 2007;Cobrinik, 2005). In doing so, RB restricts the expression of a transcriptional program that includes key regulators of cell cycle progression (for example, cyclin A and cyclin-dependent kinase (CDK) 2), DNA replication (for example, MCM7 and PCNA) and mitosis (for example, Plk1 and MAD2) (Nevins, 2001;Markey et al, 2002Markey et al, , 2007Dynlacht, 2004, 2007;Cobrinik, 2005;Iaquinta and Lees, 2007). Mitogenic signals lead to the activation of CDK/cyclin complexes that phosphorylate RB, alleviating the latent transcriptional repression and allowing for progression through the cell cycle (Weinberg, 1995;Peeper et al, 1997;Dyson, 1998).…”
Section: Introductionmentioning
confidence: 99%