Loss of Visceral Fat is Associated with a Reduction in Inflammatory Status in Patients with Metabolic Syndrome

Castro‐Barquero, Sara; Casas, Rosa; Rimm, Eric B.; Tresserra‐Rimbau, Anna; Romaguera, Dora; Martínéz, J. Alfredo; Salas‐Salvadó, Jordi; Martínez‐González, Miguel A.; Vidal, Josep; Ruíz-Canela, Miguel; Konieczna, Jadwiga; Sacanella, Emilio; García‐Gavilán, Jesús; Fitó, Montse; García‐Arellano, Ana; Estruch, Ramón

doi:10.1002/mnfr.202200264

Cited by 7 publications

(5 citation statements)

References 57 publications

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“…Nevertheless, the underlying mechanisms that explain the relationship between VAT and PD remain unclear. One possible explanation is that VAT might affect the immune system, causing changes in the inflammatory response (Castro‐Barquero et al, 2022) and the onset of PD (Machado et al, 2021). For example, VAT might affect the balance of pro‐inflammatory and anti‐inflammatory cytokines, resulting in increased inflammation and PD development (Czesnikiewicz‐Guzik et al, 2019; Kinane et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Visceral adipose tissue increases the risk of periodontal disease: Results from the 2011–2014 National Health and Nutrition Examination Survey and Mendelian randomization analysis

Qu,

Wang,

Shen

2023

J Clinic Periodontology

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AimThis study aimed to investigate the relationship and potential causal effect of visceral adipose tissue (VAT) on periodontal disease (PD). Despite prior research on this, there has been no definitive conclusion. Therefore, this study aimed to provide additional insight into these associations.Materials and MethodsThis study used data from the National Health and Nutrition Examination Survey 2011–2014 to examine the association between VAT and PD in a cross‐sectional study design. Various analytical methods were employed, such as multivariable logistic regression, restricted cubic spline analysis, and p‐value for trend. Additionally, two‐sample Mendelian randomization (MR) analysis was performed to evaluate the potential causal effect of VAT on PD risk. These methods enabled us to evaluate the association between VAT and PD and to establish whether VAT could be a causal factor in PD development.ResultsThe study examined a sample of 3535 participants, and the findings suggested that higher VAT levels were associated with an increased risk of PD. In addition, multivariable regression analysis conducted in six models revealed a statistically significant association between VAT and PD risk. Restricted cubic spline analysis showed an inverted U‐shaped association between VAT and PD, with a turning point at 733 g of VAT. Finally, a two‐sample MR analysis provided evidence for a potential causal relationship between VAT and PD risk, with an odds ratio of 1.16 (95% confidence interval: 1.02–1.33, p = .027) per kg increase in genetically predicted VAT.ConclusionsThe results of this study suggest that there is a significant association between VAT and PD and that VAT could be a potential causal factor in PD risk. Our results also suggest that although there is a potential link between VAT levels and PD risk, the effect size is modest. Therefore, interventions designed to reduce VAT levels should not be considered a primary strategy for PD risk reduction but could be one of many strategies used in a comprehensive approach to PD risk management.

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Section: Discussionmentioning

confidence: 99%

Visceral adipose tissue increases the risk of periodontal disease: Results from the 2011–2014 National Health and Nutrition Examination Survey and Mendelian randomization analysis

Qu,

Wang,

Shen

2023

J Clinic Periodontology

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“…Excess adiposity under these circumstances accelerates the aging process [12]. A few studies have reported the correlation between the changes in adipocytokine secretion with aging and obesity, under different dietary intervention, mostly in male mice [15][16][17][18][19][20]. Furthermore, fewer studies explore these changes in female mice [21].…”

Section: Introductionmentioning

confidence: 99%

Secreted Adipocytokines in Harvested Visceral Fat Differ over Age and Diet in Control and High-Fat Diet Fed Female C3H/Hej Mice

Mubtasim,

Barr,

Boren

et al. 2024

Preprint

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Excess consumption of a high-fat diet has been identified as one of the contributing factors for obesity. Women are at higher risk for adult obesity than men, predisposing them to a different set of detrimental disease conditions. Furthermore, aging studies show that physiological decline also has a serious impact on changes in the endocrine properties of white adipose tissue. Howev-er, there is still relatively little known about the factors associated with obesity and aging and their compounding impact on women’s health. To investigate adipocytokine secretion profile changes, female C3H/HeJ mice were induced to obesity through long-term consumption of a high-fat diet. Weight gain measurements and Echo MRI analysis of fat composition showed in-creases were a due solely to the high fat content in the diet. Adipocytokine secretions were ana-lyzed in media conditioned from harvested visceral fat tissue that was organ cultured ex-vivo. Adipocytokine analysis across diets and age showed significant increases in Adiponectin and Leptin secretion in high-fat diets, accelerated increases in Resistin secretion with high-fat diets. Aging induced increased secretion of Lipcalin-2, Pentraxin-3 and Serpin E1, MCP-1 and ICAM-1, regardless of diet. Furthermore, comparisons of organoid cultured protein secretions and flash-frozen tissue samples differed greatly, suggesting the WAT organoid cultures may yield information more reflective of in situ conditions. Taken together, our results show that diet and aging significantly impact secretions from adipose tissue, that may contribute to women’s health issues.

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“…Under these circumstances, excess adiposity accelerates the aging process [12]. A few studies have reported the correlation between the changes in adipocytokine secretion with aging and obesity under different dietary interventions, mostly in male mice [15][16][17][18][19][20]. Furthermore, fewer studies have explored these changes in female mice [21].…”

Section: Introductionmentioning

confidence: 99%

Effects of Aging on Secreted Adipocytokines in Visceral Fat of Female C3H/HeJ Mice Consuming a Long-Term High-Fat Diet

Mubtasim,

Barr,

Boren

et al. 2024

Dietetics

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The excess consumption of a high-fat diet has been identified as one of the factors contributing to obesity. Women are at higher risk of adult obesity than men, predisposing them to a different set of detrimental disease conditions. Furthermore, aging studies show that physiological decline also has a serious impact on changes in the endocrine properties of white adipose tissue. However, there is still relatively little known about the factors associated with obesity and aging and their compounding impacts on women’s health. To investigate changes in adipocytokine secretion profiles, obesity was induced in female C3H/HeJ mice through the long-term consumption of a high-fat diet. Weight gain measurements and the Echo MRI analysis of fat composition showed that increases were due solely to the high fat content in the diet. Adipocytokine secretions were analyzed in media conditioned from harvested visceral fat tissue that was organ-cultured ex vivo. Adipocytokine analysis performed across diets and ages showed that there were significant increases in Adiponectin and Leptin secretion in high-fat diets, accelerating increases in Resistin secretion in high-fat diets. Aging induced the increased secretion of Lipcalin-2, Pentraxin-3, Serpin E1, MCP-1, and ICAM-1, regardless of diet. Furthermore, the comparisons of organoid-cultured protein secretions and flash-frozen tissue samples differed greatly, suggesting the WAT organoid cultures may yield information that is more reflective of in situ conditions. Taken together, our results show that high-fat diets and aging in C3H/HeJ female mice significantly impact secretions from adipose tissue, which may contribute to women’s health issues.

show abstract

Loss of Visceral Fat is Associated with a Reduction in Inflammatory Status in Patients with Metabolic Syndrome

Cited by 7 publications

References 57 publications

Visceral adipose tissue increases the risk of periodontal disease: Results from the 2011–2014 National Health and Nutrition Examination Survey and Mendelian randomization analysis

Visceral adipose tissue increases the risk of periodontal disease: Results from the 2011–2014 National Health and Nutrition Examination Survey and Mendelian randomization analysis

Secreted Adipocytokines in Harvested Visceral Fat Differ over Age and Diet in Control and High-Fat Diet Fed Female C3H/Hej Mice

Effects of Aging on Secreted Adipocytokines in Visceral Fat of Female C3H/HeJ Mice Consuming a Long-Term High-Fat Diet

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