Lost in Space? Unmasking the T Cell Reaction to Simulated Space Stressors

Miranda, Silvana; Vermeesen, Randy; Radstake, Wilhelmina E.; Parisi, Alessio; Ivanova, Anna; Baatout, Sarah; Tabury, Kevin; Baselet, Bjorn

doi:10.3390/ijms242316943

Cited by 3 publications

(1 citation statement)

References 63 publications

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“…This study indicates that cortisol could have a particular influence on the development of Porphyromonas gingivalis ( Akcali et al, 2014 ; Lloro et al, 2020 ). This aligns with recent literature indicating that elevated cortisol levels have a significant effect on the immune system’s response in particular T-cells ( Miranda et al, 2023 ) and antimicrobial salivary proteins ( Agha et al, 2020 ). However, it should be noted that other studies indicated that different space flight stressors (rather than cortisol alone) may interact and produce adverse health effects amongst space travellers ( Radstake et al, 2022 ).…”

Section: The Effect Of Space Flights On Periodontal Diseasesupporting

confidence: 91%

Considerations for oral and dental tissues in holistic care during long-haul space flights

Bakr,

Caswell,

Hussein

et al. 2024

Front. Physiol.

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The health of astronauts during and after the return from long-haul space missions is paramount. There is plethora of research in the literature about the medical side of astronauts’ health, however, the dental and oral health of the space crew seem to be overlooked with limited information in the literature about the effects of the space environment and microgravity on the oral and dental tissues. In this article, we shed some light on the latest available research related to space dentistry and provide some hypotheses that could guide the directions of future research and help maintain the oral health of space crews. We also promote for the importance of regenerative medicine and dentistry as well highlight the opportunities available in the expanding field of bioprinting/biomanufacturing through utilizing the effects of microgravity on stem cells culture techniques. Finally, we provide recommendations for adopting a multidisciplinary approach for oral healthcare during long-haul space flights.

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Section: The Effect Of Space Flights On Periodontal Diseasesupporting

confidence: 91%

Considerations for oral and dental tissues in holistic care during long-haul space flights

Bakr,

Caswell,

Hussein

et al. 2024

Front. Physiol.

View full text Add to dashboard Cite

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Applications of GANIL Research Activities and Techniques

FARGET,

Roussel-Chomaz,

Chevalier

et al. 2024

nuclscitechnolopenres

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Since the first 40Ar beam accelerated 40 years ago at an energy of 44 MeV per nucleon, GANIL has undergone continuous evolution, with some major upgrades, to remain at the forefront of research in accelerator-based science. Because basic science in nuclear physics is closely linked to nuclear industry needs, GANIL can make significant contributions in the knowledge required for improving precision of nuclear data of interest for energy or health applications, as well as in the field of sustainable development. New facility NFS for neutron beams allows high accuracy nuclear data in neutron-induced reactions. Accelerated actinide beams like 238U or 232Th allow new-generation nuclear data in the field of nuclear fission. Heavy-ion beams allow the study of radiation in living organisms as part of the development of new cancer therapy techniques as well as space journeys. The instrumentation developed by GANIL offers modern dosimetry techniques for hadrontherapy. Finally, the irradiation of matter enables the investigation of new materials and more resistant electronic components for nuclear and space industries. Some of these developments are done in collaboration with local or national industries to develop the skills and innovation to meet future challenges

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Omics Studies of Tumor Cells under Microgravity Conditions

Graf,

Schulz,

Wehland

et al. 2024

IJMS

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Cancer is defined as a group of diseases characterized by abnormal cell growth, expansion, and progression with metastasis. Various signaling pathways are involved in its development. Malignant tumors exhibit a high morbidity and mortality. Cancer research increased our knowledge about some of the underlying mechanisms, but to this day, our understanding of this disease is unclear. High throughput omics technology and bioinformatics were successful in detecting some of the unknown cancer mechanisms. However, novel groundbreaking research and ideas are necessary. A stay in orbit causes biochemical and molecular biological changes in human cancer cells which are first, and above all, due to microgravity (µg). The µg-environment provides conditions that are not reachable on Earth, which allow researchers to focus on signaling pathways controlling cell growth and metastasis. Cancer research in space already demonstrated how cancer cell-exposure to µg influenced several biological processes being involved in cancer. This novel approach has the potential to fight cancer and to develop future cancer strategies. Space research has been shown to impact biological processes in cancer cells like proliferation, apoptosis, cell survival, adhesion, migration, the cytoskeleton, the extracellular matrix, focal adhesion, and growth factors, among others. This concise review focuses on publications related to genetic, transcriptional, epigenetic, proteomic, and metabolomic studies on tumor cells exposed to real space conditions or to simulated µg using simulation devices. We discuss all omics studies investigating different tumor cell types from the brain and hematological system, sarcomas, as well as thyroid, prostate, breast, gynecologic, gastrointestinal, and lung cancers, in order to gain new and innovative ideas for understanding the basic biology of cancer.

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Lost in Space? Unmasking the T Cell Reaction to Simulated Space Stressors

Cited by 3 publications

References 63 publications

Considerations for oral and dental tissues in holistic care during long-haul space flights

Considerations for oral and dental tissues in holistic care during long-haul space flights

Applications of GANIL Research Activities and Techniques

Omics Studies of Tumor Cells under Microgravity Conditions

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