Lotus essential oil improves neurite elongation and facilitates functional recovery after peripheral nerve injury

Sriraksa, Napatr; Kongsui, Ratchaniporn; Thongrong, Sitthisak

doi:10.3892/br.2022.1513

Cited by 3 publications

(3 citation statements)

References 38 publications

(41 reference statements)

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“…Additionally, nerve damage also causes sensory loss ( 3 ). Our results showed that PB treatments after injury to sciatic nerve could improve the number of DRG neurons in L4-L6 DRG and restore sensory function within 21 days.…”

Section: Discussionmentioning

confidence: 99%

“…The rats were randomly divided into 5 groups (control, sham, sciatic nerve crush (SNC), SNC + 20 mg/kg of PB, and SNC + 40 mg/kg of PB, n=6 in each group). The SNC injury was performed as described previously ( 3 ). Briefly, a single dose of 50 mg/kg sodium pentobarbital was injected intraperitoneal to anesthetize the rats.…”

Section: Methodsmentioning

confidence: 99%

“…Unlike the central nervous system (CNS), the PNS has the ability of remodeling after injury ( 2 ). PNI affects quality of life through loss of both sensory and motor functions of the injured nerve ( 3 , 4 ). Therefore, a fast reinnervation of target organs such as skin and muscle is required to restore nerve function and improve the quality of life of patients.…”

Section: Introductionmentioning

confidence: 99%

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Pinostrobin from Boesenbergia rotunda attenuates oxidative stress and promotes functional recovery in rat model of sciatic nerve crush injury

Kongsui

Surapinit

Promsrisuk

et al. 2023

Braz J Med Biol Res

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Oxidative stress plays a role in the delay of peripheral nerve regeneration after injury. The accumulation of free radicals results in nerve tissue damage and dorsal root ganglion (DRG) neuronal death. Pinostrobin (PB) is one of the bioflavonoids from Boesenbergia rotunda and has been reported to possess antioxidant capacity and numerous pharmacological activities. Therefore, this study aimed to investigate the effects of PB on peripheral nerve regeneration after injury. Male Wistar rats were randomly divided into 5 groups including control, sham, sciatic nerve crush injury (SNC), SNC + 20 mg/kg PB, and SNC + 40 mg/kg PB. Nerve functional recovery was observed every 7 days. At the end of the study, the sciatic nerve and the DRG were collected for histological and biochemical analyses. PB treatment at doses of 20 and 40 mg/kg reduced oxidative stress by up-regulating endogenous glutathione. The reduced oxidative stress in PB-treated rats resulted in increased axon diameters, greater number of DRG neurons, and p-ERK1/2 expression in addition to faster functional recovery within 4 weeks compared to untreated SNC rats. The results indicated that PB diminished the oxidative stress-induced nerve injury. These effects should be considered in the treatment of peripheral nerve injury.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%