Lotus (Nelumbo nuficera) flower essential oil increased melanogenesis in normal human melanocytes

Jeon, Songhee; Kim, Nan-Hyung; Koo, Byung-Soo; Kim, Jiyoung; Lee, Ai-Young

doi:10.3858/emm.2009.41.7.057

Cited by 28 publications

(25 citation statements)

References 24 publications

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“…The essential oil that is extracted from Vitex negundo Linn leaves has been reported to possess antioxidant and antimelanogenic activities [20]. By contrast, it has been demonstrated that the lotus flower essential oil stimulates melanin synthesis and tyrosinase activity in normal human melanocytes [21]. The C. cassia essential oil (CC-EO) has hypouricemic [22] and antifungal activities [23]; however, little information is available regarding the inhibitory action of CC-EO on tyrosinase activity and melanogenesis.…”

Section: Introductionmentioning

confidence: 99%

Cinnamomum cassia Essential Oil Inhibits α-MSH-Induced Melanin Production and Oxidative Stress in Murine B16 Melanoma Cells

Chou

Chang

et al. 2013

IJMS

119

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Essential oils extracted from aromatic plants exhibit important biological activities and have become increasingly important for the development of aromatherapy for complementary and alternative medicine. The essential oil extracted from Cinnamomum cassia Presl (CC-EO) has various functional properties; however, little information is available regarding its anti-tyrosinase and anti-melanogenic activities. In this study, 16 compounds in the CC-EO have been identified; the major components of this oil are cis-2-methoxycinnamic acid (43.06%) and cinnamaldehyde (42.37%). CC-EO and cinnamaldehyde exhibited anti-tyrosinase activities; however, cis-2-methoxycinnamic acid did not demonstrate tyrosinase inhibitory activity. In murine B16 melanoma cells stimulated with α-melanocyte-stimulating hormone (α-MSH), CC-EO and cinnamaldehyde not only reduced the melanin content and tyrosinase activity of the cells but also down-regulated tyrosinase expression without exhibiting cytotoxicity. Moreover, CC-EO and cinnamaldehyde decreased thiobarbituric acid-reactive substance (TBARS) levels and restored glutathione (GSH) and catalase activity in the α-MSH-stimulated B16 cells. These results demonstrate that CC-EO and its major component, cinnamaldehyde, possess potent anti-tyrosinase and anti-melanogenic activities that are coupled with antioxidant properties. Therefore, CC-EO may be a good source of skin-whitening agents and may have potential as an antioxidant in the future development of complementary and alternative medicine-based aromatherapy.

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Section: Introductionmentioning

confidence: 99%

Cinnamomum cassia Essential Oil Inhibits α-MSH-Induced Melanin Production and Oxidative Stress in Murine B16 Melanoma Cells

Chou

Chang

et al. 2013

IJMS

119

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“…This denotes that Tunisian aromatic plants can induce melanogenesis in B16 melanoma cells without causing transformation. Later on Jeon [5] studied the essential oil from lotus flower extract and its effects on melanogenesis in human melanocytes. It was found that the effective compound of lotus flower oil palmitic acid methyl ester induced the expression of tyrosinase, microphthalmia-associated transcription factor M Volume 2 Issue 1 -2017 (MITF-M), and tyrosinase-related proten-2 (TRP-2) proteins, but not tyrosinase mRNA.…”

Section: Effect Of Herbal Extract and Their Actives On Melanogenesismentioning

confidence: 99%

Natural Melanogenesis Stimulator a Potential Tool for the Treatment of Hypopigmentation Disease

Zaidi¹

2017

IJMBOA

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The synthesis of melanin pigments or melanogenesis has many important physiological functions that include photo protection of the human skin from ultraviolet (UV) irradiation. Melanogenesis is a complex pathway involving melanin synthesis, melanin transport, and melanosome release. Melanin synthesis is stimulated by various effects such as α-melanocyte-stimulating hormone (α-MSH); cyclic AMP (cAMP) elevating agents including palmitic acid, methyl ester, psoralen, thymoquinone, piperine, berberine and withaferin-A. Loss of the hair shaft melanin is associated with decrease of tyrosinase activity in the bulb of melanocytes. Activators of tyrosinase with stimulatory effects on melanogenesis are beneficial for the treatment of hypopigmentation diseases. This is only report authors found in literature about tyrosinase activation. Melanogenesis stimulator are rarely studied as most industries are more interested on inhibitors of the enzyme in order to reduce the adverse effects of melanin formation in, for example, processed food and human skin. Hence, there is a need to review the successful utilization of tyrosinase stimulators from natural herbs for medicinal applications.

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“…Interestingly, many natural products contain palmitates. A palmitic-acid ester in oil from the lotus flower (Nelumbo nuficera) enhances melanin production when added to melanocytes grown in vitro 16 . Coconut oil is also rich in palmitates.…”

Section: Red Alert About Lipid's Role In Skin Cancermentioning

confidence: 99%

Red alert about lipid's role in skin cancer

Jackson

Patton

2017

Nature

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Lotus (Nelumbo nuficera) flower essential oil increased melanogenesis in normal human melanocytes

Cited by 28 publications

References 24 publications

Cinnamomum cassia Essential Oil Inhibits α-MSH-Induced Melanin Production and Oxidative Stress in Murine B16 Melanoma Cells

Cinnamomum cassia Essential Oil Inhibits α-MSH-Induced Melanin Production and Oxidative Stress in Murine B16 Melanoma Cells

Natural Melanogenesis Stimulator a Potential Tool for the Treatment of Hypopigmentation Disease

Red alert about lipid's role in skin cancer

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