Louping ill in man: A forgotten disease

Davidson, M M; Williams, H.; MacLeod, John

doi:10.1016/0163-4453(91)92756-u

Cited by 86 publications

(34 citation statements)

References 25 publications

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“…The presence of both virus isolates in a pool of ticks removed from a single animal suggests that the two viruses cohabit a niche in the same tick population. The identification of a distinct Irish LI virus may explain the different symptoms exhibited in human cases of LI disease in Ireland and Great Britain (Likar & Dane, 1958 ;Davidson et al, 1991).…”

Section: Discussionmentioning

confidence: 99%

Tracing the origins of louping ill virus by molecular phylogenetic analysis.

McGuire¹,

Holmes²,

Gao³

et al. 1998

Journal of General Virology

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Section: Discussionmentioning

confidence: 99%

Tracing the origins of louping ill virus by molecular phylogenetic analysis.

McGuire¹,

Holmes²,

Gao³

et al. 1998

Journal of General Virology

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“…Moreover, there have been at least 37 documented cases of LIV infection in man, which were probably transmitted by aerosol during laboratory experimentation or diagnosis rather than by tick bites (Collins, 1988 ;Davidson et al, 1991).…”

Section: Introductionmentioning

confidence: 99%

Recombinant Semliki Forest virus particles encoding the prME or NS1 proteins of louping ill virus protect mice from lethal challenge.

Fleeton¹,

Sheahan²,

Gould³

et al. 1999

Journal of General Virology

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Recombinant Semliki Forest virus (rSFV) vaccines encoding louping ill virus (LIV)genes prME and NS1 were examined. Cells transfected with rSFV-prME RNA showed correct processing of the precursor prME and the release into the medium of M and E proteins in particulate form, whilst rSFV-NS1-transfected cells secreted glycosylated, heat-labile NS1 dimers. Mice immunized with rSFV particles produced antibodies against prME and NS1 that were mainly of the IgG2a subtype, indicating that a T-helper 1 immune response was induced. Immunization with prME-or NS1-encoding particles induced T-cell proliferation. Mice vaccinated intraperitoneally (i.p.) with rSFVprME and/or rSFV-NS1 were significantly protected from lethal i.p. challenge by two strains of LIV, the virulent LI/31 strain, from which the commercial LIV vaccine is derived, and the less-virulent LI/I antibody-escape variant. Intranasal (i.n.) vaccination was protective for rSFV-prME only against LI/31 challenge and not against challenge with LI/I. Immunization with rSFV-NS1 was protective against i.p. and i.n. challenge with both virus strains when given i.p., but was not protective when given i.n. For unvaccinated mice infected with LIV, all animals showing clinical signs had severe degenerative and inflammatory lesions in the central nervous system. None of the rSFV-vaccinated mice that survived challenge showed central nervous system pathology, with the exception of mild leptomeningitis in a minority of LI/31-infected mice. This suggests that protection following immunization with rSFV must occur at early stages of LIV infection.

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“…Koyunların hastalığı olarak bilinen Louping hastalığı ender olarak insanlarda da görülmekte-dir. İlk insan enfeksiyonu 1934 yılında bildirilmiştir (33) . Hastalık koyun çobanlığı yapan, mezbahalarda koyun kesimi ile ilgilenen kişiler-de hayvan sağlığı ile ilgili meslek gruplarında ya da laboratuvar çalışanlarında görülmüştür (34) .…”

Section: Louping Ill Virüs (Liv Louping Hastalığı Virüsü)unclassified

“…Bu virüsün enfeksiyonları bu kenelerin görüldüğü İngiltere, İskoçya ve diğer Avrupa ülkelerinde yaygındır (33) . Ağırlıklı olarak ormanlık alanlarda bulunan ve küçük kemirgenlerin rezervuarlığını yaptığı Batı TBEV'den farklı olarak, LIV genellikle küçük kemirgenler tarafından değil, koyun, orman tavuğu ve dağ tavşanları tarafından bulaştırılmaktadır (32) .…”

Section: Louping Ill Virüs (Liv Louping Hastalığı Virüsü)unclassified

An overview of tick-borne viral pathogens in the light of current literature

Aktaş¹,

Aydın²

2017

TMCD

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An Overview of Tick-Borne Viral Pathogens in the Light of Current Literature Keywords: Tick-borne viruses, Heartland virus, CrimeanCongo hemorrhagic fever GiRiŞKenelere ilişkin ilk yazılara kene humması hakkında MÖ 1550 tarihli Mısır papirüslerinde rastlandığı, yazarı bilinen ilk yazıların ise MÖ 800 yılında Homeros tarafından yazıldığı sanılmaktadır (1) . Hastalıklarla ilişkisi yüzyıllar öncesinden bilinen keneler, insan ve hayvanlarda ölümle sonuçlanabilen çeşitli enfeksiyon etkenlerini taşımaları ile günümüze önemini arttırarak gelmişlerdir.Karasal omurgalı canlı gruplarının tüm sınıfları-nın zorunlu dış paraziti olan kenelerin tek besin

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Louping ill in man: A forgotten disease

Cited by 86 publications

References 25 publications

Tracing the origins of louping ill virus by molecular phylogenetic analysis.

Tracing the origins of louping ill virus by molecular phylogenetic analysis.

Recombinant Semliki Forest virus particles encoding the prME or NS1 proteins of louping ill virus protect mice from lethal challenge.

An overview of tick-borne viral pathogens in the light of current literature

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