Lovastatin increases exercise-induced skeletal muscle injury

Thompson, Paul D.; Zmuda, Joseph M.; Domalik, Leslie J.; Zimet, Richard; Staggers, Joan E.; Guyton, John R.

doi:10.1016/s0026-0495(97)90218-3

Cited by 160 publications

(116 citation statements)

References 22 publications

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“…Serum CoQ 10 was not measured because it is well known that CoQ 10 levels in blood correlate poorly with intramuscular levels (Paiva et al 2005). In contrast to Thompson et al(1997), we did not find an exacerbation of exercise-induced skeletal muscle injury after statin treatment. In fact, the acute changes in CK levels from rest to 24 h after completing the exercise testing were only significant at baseline (mean change=80 IU/l or 79.8%, P<0.05) and not at 12 weeks (mean change=15 IU/l or 9.5%, NS).…”

Section: Discussioncontrasting

confidence: 66%

High-dose statin use does not impair aerobic capacity or skeletal muscle function in older adults

Traustadóttir

Stock

Harman

2008

AGE

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3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) are lipidlowering agents widely employed for atherosclerosis prevention. HMG-CoA reductase blockade reduces skeletal muscle coenzyme Q 10 (CoQ 10 ) levels and mitochondrial respiratory chain activities and may produce mild to severe skeletal muscle myopathy. This study investigated whether high-dose statin treatment would result in measurably decreased exercise capacity in older men and women. Maximal oxygen consumption, aerobic endurance, oxygen uptake kinetics, maximal strength, muscular power, and muscular endurance were measured before and after 12 weeks of statin treatment (simvastatin, 80 mg/day) in nine men and one woman, ages 55-76 years, with LDL-cholesterol levels >3.3 mmol/l (mean=4.2±0.2 mmol/l). Myalgia symptoms were assessed every 4 weeks. As expected, statin treatment resulted in significant decreases in LDL-and total-cholesterol levels (P<0.01) with no significant changes in HDL-cholesterol or triglyceride levels. No significant changes were observed in aerobic capacity, endurance, oxygen kinetics or any measures of muscle function. No subject reported symptoms of myalgia, cramps, or weakness during the study. In the absence of myalgia or myopathic symptoms, high-dose simvastatin treatment did not impair exercise capacity in hyperlipidemic older individuals. We conclude that decreases in intramuscular CoQ 10 , in most patients on high dose statin treatment may not be clinically relevant, due to inter-individual variability in the degree of CoQ 10 depletion, sensitivity of muscle to decreases in CoQ 10 , or both.

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Section: Discussioncontrasting

confidence: 66%

High-dose statin use does not impair aerobic capacity or skeletal muscle function in older adults

Traustadóttir

Stock

Harman

2008

AGE

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“…Thompson et al. also noticed that statin therapy might exacerbate exercise-induced skeletal muscle injury even after less intense training (45 min of downhill treadmill walking (-15% grade) at 65% of their predetermined maximum heart rate) [78]. [47] Severe irritability [48], insomnia, somnolence, agitation, confusion, hallucinations [49] and nightmares [50] Endocrine ↑ Risk of NOD from 9-27% [36,38,39,51] Intensive-dose statin therapy is associated with a 12% higher incidence of NOD compared with moderate-dose statin therapy [38,51] Gastrointestinal tract…”

Section: Physical Activity and Statin Intolerancementioning

confidence: 99%

Statin intolerance – an attempt at a unified definition. Position paper from an International Lipid Expert Panel

Banach

Rizzo²,

Tóth

et al. 2015

Expert Opinion on Drug Safety

182

204

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“…This result demonstrates that the transminase increase produced by statins is a direct consequence of inhibition of mevalonate synthesis. Thompson et al reported that lovastatin increases exercise-induced skeletal muscle injury (24,25). Chariot et al (26), reported a case with simvastatin-induced rhabdomyolysis followed by a MELAS syndrome, suggesting that statin-induced complications are due to a mitochondrial dysfunction through CoQ10 deficiency.…”

Section: Statin Coq10 and Rhabdomyolysis And Liver Dysfunctionmentioning

confidence: 99%

Reduction of Serum Ubiquinol-10 and Ubiquinone-10 Levels by Atorvastatin in Hypercholesterolemic Patients

Mabuchi

Higashikata

Kawashiri

et al. 2005

JAT

107

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Reduction of serum cholesterol levels with statin therapy decreases the risk of coronary heart disease. Inhibition of HMG-CoA reductase by statin results in decreased synthesis of cholesterol and other products downstream of mevalonate, which may produce adverse effects in statin therapy. We studied the reductions of serum ubiquinol-10 and ubiquinone-10 levels in hypercholesterolemic patients treated with atorvastatin. Fourteen patients were treated with 10 mg/day of atorvastatin, and serum lipid, ubiquinol-10 and ubiquinone-10 levels were measured before and after 8 weeks of treatment. Serum total cholesterol and LDL-cholesterol levels decreased significantly. All patients showed definite reductions of serum ubiquinol-10 and ubiquinone-10 levels, and mean levels of serum ubiquinol-10 and ubiquinone-10 levels decreased significantly from 0.81 ± ± ± ± ± 0.21 to 0.46 ± ± ± ± ± 0.10 µ µ µ µ µg/ml (p < 0.0001), and from 0.10 ± ± ± ± ± 0.06 to 0.06 ± ± ± ± ± 0.02 µ µ µ µ µg/ml (p = 0.0008), respectively. Percent reductions of ubiquinol-10 and those of total cholesterol showed a positive correlation (r = 0.627, p = 0.0165). As atorvastatin reduces serum ubiquinol-10 as well as serum cholesterol levels in all patients, it is imperative that physicians are forewarned about the risks associated with ubiquinol-10 depletion. J Atheroscler Thromb, 2005; 12: 111-119.

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Lovastatin increases exercise-induced skeletal muscle injury

Cited by 160 publications

References 22 publications

High-dose statin use does not impair aerobic capacity or skeletal muscle function in older adults

High-dose statin use does not impair aerobic capacity or skeletal muscle function in older adults

Statin intolerance – an attempt at a unified definition. Position paper from an International Lipid Expert Panel

Reduction of Serum Ubiquinol-10 and Ubiquinone-10 Levels by Atorvastatin in Hypercholesterolemic Patients

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