Lovastatin inhibits adipogenesis and prevents osteonecrosis in steroid-treated rabbits

Kang, Pengde; Pei, Fuxing; Shen, Bin; Yang, Jing; Cheng, Jun

doi:10.1016/j.jbspin.2007.12.008

Cited by 74 publications

(77 citation statements)

References 16 publications

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“…Until now, no data on the safety and efficacy of statin use for prevention and/or treatment of early-stage ON in children with ALL have been available. 47 Moreover, no clinical data on the role of drug-drug interactions with statins and vincristine/ glucocorticoids are available. Beyond that, the use of statins seems to be most effective when given preemptively and not as a pharmacological intervention in manifest ON.…”

Section: Pharmacological Interventionsmentioning

confidence: 99%

“…A detailed summary of pharmacological intervention studies and their outcomes is presented in Table 2. 29,31,35,[37][38][39][40]42,47 Prospective clinical trials are needed to elucidate potential toxicities and thus to facilitate an accurate risk/benefit analysis of these pharmacological interventions. ACTH, adrenocorticotropic hormone; ALCL, anaplastic large cell lymphoma; AML, acute myeloid leukemia; ARCO, association research circulation osseous; AVN, avascular necrosis; BME, bone marrow edema; BMT, bone marrow transplantation; GCS, glucocorticosteroids; HL, Hodgkin lymphoma; HR, high risk; LMW, low molecular weight; NHL, non-Hodgkin lymphoma; n.s., not specified; ON, osteonecrosis; po, by mouth; pts, patients; SR, standard risk.…”

Section: Pharmacological Interventionsmentioning

confidence: 99%

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Osteonecrosis in children and adolescents with acute lymphoblastic leukemia: a therapeutic challenge

et al. 2017

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Osteonecrosis (ON) represents one of the most common and debilitating sequelae of antileukemic treatment in children and adolescents with acute lymphoblastic leukemia (ALL). Systematic screening strategies can focus on early detection and intervention to prevent ON from progressing to stages associated with pain and functional impairment.These strategies hold promise for reducing ON-associated morbidity without the risk of impairing leukemia control. Herein, we critically reviewed clinical data on pharmacological, nonpharmacological/nonsurgical, and surgical (including cellular) treatment options for ON, which are covered in the literature and/or are conceivable based on the supposed underlying ON pathophysiology. Prevention of ON progression is of paramount importance, and attempts seem to be more effective in early (precollapse) disease status than in late-stage (collapse) ON. Based on the results of ongoing prospective magnetic resonance imaging screening studies, which will hopefully identify those patients with a high risk of ON progression and debilitating sequelae, prospective interventional studies are urgently needed. Although there is still a lack of high-quality studies, based on currently available data, core decompression surgery combined with cellular therapies (eg, employing mesenchymal stem cells) appears most promising for preventing joint infraction in children at high risk of developing late-stage ON.

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Section: Pharmacological Interventionsmentioning

confidence: 99%

Section: Pharmacological Interventionsmentioning

confidence: 99%

Osteonecrosis in children and adolescents with acute lymphoblastic leukemia: a therapeutic challenge

et al. 2017

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“…Пациенты с высоким уровнем холестерина или три-глицеридов могут потребовать назначения статинов. Экспериментальные данные показали, что назначение статинов (ловастатина) способно предупредить раз-витие стероидиндуцированного остеонекроза [34,35]. Одной из целей лечения аваскулярных некрозов являет-ся облегчение боли (с помощью фармакологических или хирургических подходов).…”

Section: обсуждение основного результата исследованияunclassified

Bone Mineral Turnover after Allogeneic Hematopoietic Stem Cell Transplantation in Children: A Single Center Cohort Study

Скворцова¹,

Balashov²,

Скоробогатова³

et al. 2017

Pediatr. farmakol.

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Нарушения костного минерального обмена являются поздними осложнениями аллогенной трансплантации гемо-поэтических стволовых клеток (ТГСК) у детей. Цель исследования -определить частоту и факторы риска наруше 2 против 8, р=0,001), хроническая РТПХ (36,0% при экстенсивной форме против 14,5% при ограниченной форме и 8,4% при отсутствии хронической РТПХ; р<0,001), иммуносупрессивная терапия >12 мес (31,9 против 6,9% при длительности <3 мес; р<0,001), прием глюкокортикостероидов >3 мес (93,8 против 8,1% при приеме 3 мес и 3,2% без терапии; р<0,001

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“…Lipid-lowering drugs such as statins decrease the incidence of steroid-induced osteonecrosis [73,74] . Other studies have also shown that the simultaneous use of anticoagulants along with lipid-lowering agents can decrease the prevalence of steroid-induced osteonecrosis in rabbits [75,76] .…”

Section: Update On Bench Research and Clinical Applicationsmentioning

confidence: 99%

Osteonecrosis of the femoral head: An update in year 2012

Kaushik

Das²,

Cui³

2012

WJO

138

118

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Osteonecrosis is a phenomenon involving disruption to the vascular supply to the femoral head, resulting in articular surface collapse and eventual osteoarthritis. Although alcoholism, steroid use, and hip trauma remain the most common causes, several other etiologies for osteonecrosis have been identified. Basic science research utilizing animal models and stem cell applications continue to further elucidate the pathophysiology of osteonecrosis and promise novel treatment options in the future. Clinical studies evaluating modern joint-sparing procedures have demonstrated significant improvements in outcomes, but hip arthroplasty is still the most common procedure performed in these affected younger adults. Further advances in joint-preserving procedures are required and will be widely studied in the coming decade.

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Lovastatin inhibits adipogenesis and prevents osteonecrosis in steroid-treated rabbits

Cited by 74 publications

References 16 publications

Osteonecrosis in children and adolescents with acute lymphoblastic leukemia: a therapeutic challenge

Osteonecrosis in children and adolescents with acute lymphoblastic leukemia: a therapeutic challenge

Bone Mineral Turnover after Allogeneic Hematopoietic Stem Cell Transplantation in Children: A Single Center Cohort Study

Osteonecrosis of the femoral head: An update in year 2012

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