Low 25-hydroxyvitamin D level is associated with insulin sensitivity in obese adolescents with non-alcoholic fatty liver disease

Pirgon, Özgür; Çekmez, Ferhat; Bilgin, Hüseyin; Eren, Esra; Dündar, Bumin Nuri

doi:10.1016/j.orcp.2012.01.004

Cited by 34 publications

(36 citation statements)

References 43 publications

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“…For example, HDL‐C levels were positively related to 25(OH)D levels in US adolescents from NHANES 2001–2006 (Williams et al, ). Impaired glucose metabolism and IR have been correlated with vitamin D deficiency or low 25(OH)D levels in children in some studies (Rajakumar et al, ; Williams et al, ), but not all (de las Heras et al, ; Pirgon et al, ). Lower 25(OH)D levels were associated with approximately 3.9 times higher odds of having metabolic syndrome independent of BMI (Reis et al, ).…”

Section: Introductionmentioning

confidence: 99%

Inverse associations between cardiometabolic risk factors and 25‐hydroxyvitamin D in obese American children and adolescents

Lee

Ebert

Kadakia

et al. 2016

American J Hum Biol

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Section: Introductionmentioning

confidence: 99%

Inverse associations between cardiometabolic risk factors and 25‐hydroxyvitamin D in obese American children and adolescents

Lee

Ebert

Kadakia

et al. 2016

American J Hum Biol

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“…47 Two separate observational studies showed that compared with non-NAFLD obese children and teens, those with NAFLD had significantly lower serum concentrations of 25(OH)D, which was correlated with IR in those with NAFLD but not in those without NAFLD. 48,49 Another investigation showed that lower 25(OH)D concentration is associated with NAFLD, independent of adiposity, physical activity, and IR. 50 At odds with these findings, an earlier report using data on 1,630 children, aged 12-19 years, from the National Health and Examination Survey (NHANES) 2001-2004, found vitamin D status not to be independently associated with NAFLD.…”

mentioning

confidence: 99%

“…50 At odds with these findings, an earlier report using data on 1,630 children, aged 12-19 years, from the National Health and Examination Survey (NHANES) 2001-2004, found vitamin D status not to be independently associated with NAFLD. 51 It remains to be determined whether poor vitamin D status contributes directly to the risk of developing NAFLD or if this association is confounded by hepatosteatosis, 48 as the liver is a primary site of vitamin D activation.…”

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confidence: 99%

Vitamin D deficiency and childhood obesity: interactions, implications, and recommendations

Peterson¹

2015

NDS

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Vitamin D deficiency and childhood obesity have been classified as epidemics throughout the world, and both share some common risk factors including poor diet and inactivity. Observational and clinical studies show that vitamin D status and fat mass are inversely correlated. It is not clear whether vitamin D deficiency contributes to, or is a consequence of obesity, or whether there are regulatory interactions between excess adiposity and vitamin D activity. The effects of this deficiency in childhood obesity appear to have negative influences on overall health, including insulin resistance, inflammation, and impeded bone mineralization, as well as increased future risk of type 2 diabetes, cardiovascular disease, and osteoporosis. The rather ubiquitous distribution of the vitamin D receptor and the 25-hydroxyvitamin D 1α-hydroxylase throughout the body, including evidence for a role of vitamin D in adipogenesis and adipocyte metabolism, may in part explain these widespread effects. Most of the findings to date suggest that the vitamin D needs of obese children are greater than the nonobese. Although ultraviolet B-induced skin synthesis is a main source of vitamin D, its use is neither feasible nor prudent due to limited sun availability for many and concerns for skin cancer. Likewise, obtaining adequate vitamin D from natural food sources alone is generally not achievable, and even in countries that allow fortification, vitamin D intakes are low. Therefore, in obese children, vitamin D supplementation is warranted. Weight loss interventions using energy restriction and physical activity may also improve the poor vitamin D status associated with obesity. More research is needed to define optimal vitamin D status in this vulnerable population, including investigations to determine the efficacy of vitamin D supplementation in attenuating the conditions associated with childhood obesity, and to further elucidate the mechanisms by which vitamin D exerts its effects on health.

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“…In particular, low serum 25-hydroxyvitamin D (25[OH]D 3 ) levels were measured among NAFLD patients compared with controls in several studies. These are summarized in Table 1 (15)(16)(17)(18)(19).…”

Section: Dietary Patterns In Nafldmentioning

confidence: 99%

Nonmedicinal Interventions in Nonalcoholic Fatty Liver Disease

Neuman

Nanau

Cohen

2015

Canadian Journal of Gastroenterology and Hepatology

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Unhealthy diet and lack of physical exercise are responsible for fat accumulation in the liver, which may lead to liver disease. Histologically, the severity of the disease has two stages: nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). NAFLD is defined by the presence of steatosis with no evidence of cellular injury such as hepatocyte ballooning. NASH is a distinct entity from NAFLD, and is characterized by the presence of inflammation with hepatocytes damage, with or without fibrosis. While several therapeutic strategies have been proposed to improve this condition, the present review aims to discuss nonmedicinal interventions used to reduce liver involvement or to prevent the disease altogether. The authors investigated dietary patterns and vitamin deficiencies associated with NAFLD, and their role in enhancing disease severity. Additionally, they reviewed the role of exercise and the use of interventions, such as as intragastric balloon and bariatric surgery, for improving disease progression. The authors propose monitoring disease progression or repair by following changes in cytoadipokine levels.

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Low 25-hydroxyvitamin D level is associated with insulin sensitivity in obese adolescents with non-alcoholic fatty liver disease

Cited by 34 publications

References 43 publications

Inverse associations between cardiometabolic risk factors and 25‐hydroxyvitamin D in obese American children and adolescents

Inverse associations between cardiometabolic risk factors and 25‐hydroxyvitamin D in obese American children and adolescents

Vitamin D deficiency and childhood obesity: interactions, implications, and recommendations

Nonmedicinal Interventions in Nonalcoholic Fatty Liver Disease

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