Low 25-OH vitamin D levels are not associated with coronary artery calcium or obstructive stenoses

Ho, John S.; Cannaday, John J.; Barlow, Carolyn E.; Reinhardt, Dale B.; Wade, Wendy A.; Ellis, Joe

doi:10.1097/mca.0000000000000261

Cited by 18 publications

(15 citation statements)

References 20 publications

(23 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our study demonstrated that there is indeed a relationship between serum vitamin D levels and severity of CAD. These results are contrary to those of Ho et al;28 however, this disparity could be attributed to differences in geographic location and ethnicity, as well as a lower CAD prevalence in that study and the absence of female participants. Furthermore, the relatively small sample in the present study was also a contributing factor.…”

Section: Discussioncontrasting

confidence: 99%

Evaluation of vitamin D levels in relation to coronary CT angiographic findings in an Iranian population

Moradi¹,

Foroutanfar²

2017

VHRM

View full text Add to dashboard Cite

BackgroundVitamin D deficiency, as a predisposing factor for coronary artery disease (CAD), is a subject of increasing interest. However, its role as a risk factor has not been proven. This study aimed to investigate the relationship between serum vitamin D levels and CAD.Materials and methodsUsing a cross-sectional design, 180 patients who were candidates for coronary computed tomography angiography (CCTA) were selected. Serum levels of vitamin D were measured and compared with the results of CCTA (including calcium score, and presence and severity of coronary artery involvement due to atherosclerotic plaques).ResultsThe mean age of the participants was 60.5±10.6 years and the mean serum vitamin D level was 26.2±15.9 ng/dL (range, 3.5–83.2 ng/dL). Overall, 6.1% of the participants (n=11) had vitamin D deficiency, 56.1% (n=101) had insufficient levels of vitamin D, and 37.8% (n=68) had sufficient levels of vitamin D. The mean serum vitamin D level was significantly lower in patients with severe CAD (P=0.004). The serum vitamin D level in the “positive for CAD” group was 20.98 ng/mL, significantly lower than the level in the “negative for CAD” group (30.47 ng/mL; P<0.001). The mean calcium score among participants was 533.5±87.9. Based on the Spearman test, a significant negative correlation (−0.21) was detected between the serum vitamin D level and coronary artery calcium score (CACS) (P=0.005). Conversely, the mean CACS in the vitamin D deficient group was significantly higher than in the insufficient and sufficient vitamin D groups (P<0.001 for both comparisons).ConclusionVitamin D deficiency was associated with coronary artery calcification and severity of coronary artery stenosis in Iranian patients.

show abstract

Section: Discussioncontrasting

confidence: 99%

Evaluation of vitamin D levels in relation to coronary CT angiographic findings in an Iranian population

Moradi¹,

Foroutanfar²

2017

VHRM

View full text Add to dashboard Cite

show abstract

“…This observation was made in dialysis patients where a U-shape curve has been noticed, where low serum vitamin D levels, as well as high levels, are associated with vascular calcification [13,50,51]. However, other authors have postulated that there is insufficient evidence to support a consistent association between low vitamin D levels and coronary artery calcium (CAC) [55], or that there is definitely no association between low 25(OH)D and CAC, or severely obstructive coronary artery stenosis [56]. Nevertheless, single nucleotide polymorphisms (SNPs) in the CYP24A1 gene, associated with vitamin D metabolism, have been independently linked with coronary artery calcification [57].…”

Section: Methodsmentioning

confidence: 99%

Vitamin D and its effects on cardiovascular diseases: a comprehensive review

Pérez-Hernández

Aptilon-Duque

Nostroza-Hernández

et al. 2016

Korean J Intern Med

View full text Add to dashboard Cite

Vitamin D is a molecule that is actively involved in multiple metabolic pathways. It is mostly known for its implications related to calcium metabolism. It has also been determined that it actively participates in the cardiovascular system, influencing blood pressure, coronary artery disease and other vascular diseases, such as heart failure and atrial fibrillation. Furthermore, it has been established that this vitamin is extensively involved in the regulation of both the renin angiotensin aldosterone system and the immune system. In this review, we present the different vitamin D metabolic pathways associated with the cardiovascular pathophysiology, and we include studies in animal and human models, as well as some of the controversies found in the literature. This review also incorporates an overview of the implications in the molecular biology and public health fields.

show abstract

“…Vitamin D receptors can be found in most tissues including heart muscle. It has some important roles in maintaining normal function of muscles and controlling the inflammatory process and immune system [21]. Another explanation of the relation of vitamin D deficiency and CAD can be the vitamin D deficiency associated abnormalities such as metabolic syndrome, obesity, insulin resistance, diabetes, hypertension and hyperlipidemia, which all have significant relationship with cardiovascular abnormalities [6,20,22,23].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Levels Assessment in Relation to Coronary MDCT Angiographic Findings

Tantawy¹,

Hasanin

Farid

2019

Zagazig University Medical Journal

View full text Add to dashboard Cite

Background: Although vitamin D has a major role at the skeletal mineralization, it has been implicated at cardio vascular system, owing to abundance of its receptor there. Atherosclerosis is the most presenting symptom of the cardio-vascular system that warrants the urge to detect the effect of vitamin D serum level changes in progression of the atherosclerosis. Objective is to assess the correlation between vitamin D level and coronary artery findings using MDCT. Methods: Two hundred and Fifty patients were included in our study, all of them underwent MDCT for coronary artery angiography, and then the findings were compared with vitamin D serum levels. Results: 4 % of all examined patients (n=10) had vitamin D deficiency, 44 % (n=110) had insufficient levels of vitamin D, 52 % have sufficient vitamin D level (n=130). There is significant positive correlation between Lab. vitamin D levels and coronary artery calcium score (CACS) with P<0.005. Conclusions: Vitamin D levels play significant role in modifying the risk of coronary artery involvement.

show abstract

Low 25-OH vitamin D levels are not associated with coronary artery calcium or obstructive stenoses

Abstract: Low 25-OH vitamin D levels were not associated with CAC or severely obstructive stenoses.

Cited by 18 publications

References 20 publications

Evaluation of vitamin D levels in relation to coronary CT angiographic findings in an Iranian population

Evaluation of vitamin D levels in relation to coronary CT angiographic findings in an Iranian population

Vitamin D and its effects on cardiovascular diseases: a comprehensive review

Vitamin D Levels Assessment in Relation to Coronary MDCT Angiographic Findings

Contact Info

Product

Resources

About