Low adherence to the western and high adherence to the mediterranean dietary patterns could prevent colorectal cancer

Castelló, Adela; Amiano, Pilar; Larrea, Nerea Fernández de; Martín, Vicente; Alonso, M. Henar; Castaño‐Vinyals, Gemma; Pérez‐Gómez, Beatriz; Olmedo-Requena, Rocío; Guevara, Marcela; Fernández‐Tardón, Guillermo; Dierssen-Sotos, Trinidad; Llorens-Ivorra, Cristóbal; Huerta, José María; Capelo, Rocío; Fernández‐Villa, Tania; Díez-Villanueva, Anna; Urtiaga, Carmen; Castilla, Jesús; Jiménez-Moleón, José Juan; Moreno, Vı́ctor; Dávila-Batista, Verónica; Kogevinas, Manolis; Aragonés, Núria; Pollán, Marina

doi:10.1007/s00394-018-1674-5

Cited by 146 publications

(67 citation statements)

References 48 publications

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“…In order to better elucidate the role of these types of interactions in the etiology of CRC, the aim of this study was to analyze them in a sample of cases and controls from the population-based bowel cancer screening program (BCSP) of the Osakidetza/Basque Health Service. The main advantage of the present study compared to other similar research [23][24][25] is that we confirmed that controls were free of the disease through colonoscopy. Colonoscopy was used as the diagnosis criterion to identify the cases in order to avoid false positives and negatives.…”

Section: Introductionsupporting

confidence: 62%

Gene–Diet Interactions in Colorectal Cancer: Survey Design, Instruments, Participants and Descriptive Data of a Case–Control Study in the Basque Country

Alegría-Lertxundi

Aguirre

Bujanda³

et al. 2020

Nutrients

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Epidemiologic studies have revealed inconsistent evidence of gene-diet interaction in relation to colorectal cancer (CRC). The aim of this study was to analyze them in a sample of cases and controls from the population-based bowel cancer screening program of the Osakidetza/Basque Health Service. This study analyzed dietetic, genetic, demographic, socioeconomic factors and lifestyles. In the present manuscript, the survey design, sampling, instruments, measurements and related quality management were presented. Moreover, we analyze differences between cases and controls in some data, especially those related to diet. The participants were 308 cases and 308 age- and sex-matched subjects as controls. Cases were more likely than controls to have overweight/obesity (67.5% vs. 58.1%, p < 0.05), a lower intake of vitamin B2 (0.86 ± 0.23 vs. 0.92 ± 0.23 mg/1000 kcal, p < 0.01) and calcium:phosphorus ratio (0.62 ± 0.12 vs. 0.65 ± 0.13, p < 0.01). A higher proportion of cases than controls did not meet the Nutritional Objectives for saturated fatty acids (85.7% vs. 67.5%, p < 0.001) or cholesterol (35.4% vs. 25.0%, p < 0.01). In conclusion, the present study provides valuable data for analyzing the complexity of gene-diet interaction in relation to CRC. The results presented here suggest that overweight/obesity and a high intake of certain dietary components, especially saturated fatty acids and cholesterol, are more frequent in cases than in controls.

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Section: Introductionsupporting

confidence: 62%

Gene–Diet Interactions in Colorectal Cancer: Survey Design, Instruments, Participants and Descriptive Data of a Case–Control Study in the Basque Country

Alegría-Lertxundi

Aguirre

Bujanda³

et al. 2020

Nutrients

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“…Non‐Mediterranean Western diet, obesity, little physical activity, high consumption of red and processed meat, and low fiber intake are the most relevant risk factors for developing CRC (Castelló et al ., ; Edwards et al ., ; Hessami Arani and Kerachian, ; Slattery et al ., , ; Thune and Lund, ). There is a recently increased incidence of obesity in the USA, especially among young patients, and, being a well‐known risk factor for CRC, this may have played a role in reducing the age of CRC onset (Aleksandrova et al ., ; Bailey et al ., ; Bassett et al ., ; Hedley et al ., ).…”

Section: Methodsmentioning

confidence: 98%

Early‐onset colorectal cancer in young individuals

et al. 2018

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Treatment of young adults with colorectal cancer (CRC) represents an unmet clinical need, especially as diagnosis in this population might lead to the greatest loss of years of life. Since 1994, CRC incidence in individuals younger than 50 years has been increasing by 2% per year. The surge in CRC incidence in young adults is particularly alarming as the overall CRC frequency has been decreasing. Early‐onset CRC are characterized by a more advanced stage at diagnosis, poorer cell differentiation, higher prevalence of signet ring cell histology, and left colon‐sided location of the primary tumor. Among EO‐CRC, approximately 30% of patients are affected by tumors harboring mutations causing hereditary cancer predisposing syndromes, and 20% have familial CRC. Most notably, the remaining 50% of EO‐CRC patients have neither hereditary syndromes nor familial CRC, thus representing a formidable challenge for research. In this review article we summarize epidemiology, clinical and molecular features, heredity and outcome of treatments of EO‐CRC, and provide considerations for future perspectives.

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“…Scores of adherence to dietary patterns can be calculated following the exact same rules over different populations, resulting in different levels of adherence while still being valid, as has been recently proved. 35 As a matter of fact, the current dietary patterns had previously been constructed in the MCC-study and a Western dietary pattern was positively associated with gastric, 48 breast 49 and colorectal 50 cancers.…”

Section: Discussionmentioning

confidence: 99%

Adherence to the Western, Prudent, and Mediterranean dietary patterns and chronic lymphocytic leukemia in the MCC-Spain study

et al. 2018

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Diet is a modifiable risk factor for several neoplasms but evidence for chronic lymphocytic leukemia (CLL) is sparse. Previous studies examining the association between single-food items and CLL risk have yielded mixed results, while few studies have been conducted on overall diet, reporting inconclusive findings. This study aimed to evaluate the association between adherence to three dietary patterns and CLL in the multicase-control study (MCC-Spain) study. Anthropometric, sociodemographic, medical and dietary information was collected for 369 CLL cases and 1605 controls. Three validated dietary patterns, Western, Prudent and Mediterranean, were reconstructed in the MCC-Spain data. The association between adherence to each dietary pattern and CLL was assessed, overall and by Rai stage, using mixed logistic regression models adjusted for potential confounders. High adherence to a Western dietary pattern (i.e. high intake of high-fat dairy products, processed meat, refined grains, sweets, caloric drinks, and convenience food) was associated with CLL [ORQ4 vs. Q1=1.63 (95%CI 1.11; 2.39); P-trend=0.02; OR 1-SD increase=1.19 (95%CI: 1.03; 1.37)], independently of Rai stages. No differences in the association were observed according to sex, Body Mass Index, energy intake, tobacco, physical activity, working on a farm, or family history of hematologic malignancies. No associations were observed for Mediterranean and Prudent dietary patterns and CLL. This study provides the first evidence for an association between a Western dietary pattern and CLL, suggesting that a proportion of CLL cases could be prevented by modifying dietary habits. Further research, especially with a prospective design, is warranted to confirm these findings.

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Low adherence to the western and high adherence to the mediterranean dietary patterns could prevent colorectal cancer

Cited by 146 publications

References 48 publications

Gene–Diet Interactions in Colorectal Cancer: Survey Design, Instruments, Participants and Descriptive Data of a Case–Control Study in the Basque Country

Gene–Diet Interactions in Colorectal Cancer: Survey Design, Instruments, Participants and Descriptive Data of a Case–Control Study in the Basque Country

Early‐onset colorectal cancer in young individuals

Adherence to the Western, Prudent, and Mediterranean dietary patterns and chronic lymphocytic leukemia in the MCC-Spain study

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