2019
DOI: 10.3233/jad-190800
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Low Amyloid-PET Uptake in Iowa-Type Cerebral Amyloid Angiopathy with Cerebral Venous Thrombosis

Abstract: Hereditary cerebral amyloid angiopathies (CAA) are rare disorders of early onset and severe course. We describe a 47-year-old patient with Iowa-type amyloid precursor protein (APP) mutation-related hereditary CAA that manifested with concomitant lobar hemorrhage and venous sinus thrombosis. To analyze the cerebral amyloid-␤ burden, an amyloid-PET was performed, demonstrating low cortical retention except for the calcarine cortex. High amyloid retention was also found in the thalamus and pallidum. The co-occurr… Show more

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Cited by 4 publications
(2 citation statements)
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“…In agreement with our hypothesis, the SUVr O/PC ratio was significantly lower in probable CAA as compared to AD, entirely consistent with the previously reported early-phase PiB uptake results, [22] study, we aimed here to mimic as far as possible the clinical setting, both in terms of PET radiotracer and image analysis. Thus, we used for image and VOI analysis CortexID suite, which has formerly been used in the scientific literature [33][34][35][36] and has the advantage of being widely available in daily routine, making our results potentially translatable to the clinical setting. Despite all these differences, we were able to repeat Farid et al's results, further establishing the robustness of these authors' findings with respect not just to CAA phenotype and radiotracer, but also to variations in image processing pipeline.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…In agreement with our hypothesis, the SUVr O/PC ratio was significantly lower in probable CAA as compared to AD, entirely consistent with the previously reported early-phase PiB uptake results, [22] study, we aimed here to mimic as far as possible the clinical setting, both in terms of PET radiotracer and image analysis. Thus, we used for image and VOI analysis CortexID suite, which has formerly been used in the scientific literature [33][34][35][36] and has the advantage of being widely available in daily routine, making our results potentially translatable to the clinical setting. Despite all these differences, we were able to repeat Farid et al's results, further establishing the robustness of these authors' findings with respect not just to CAA phenotype and radiotracer, but also to variations in image processing pipeline.…”
Section: Resultsmentioning
confidence: 99%
“…To this end, we used CortexID Suite (GE Healthcare), as described in previous articles. [33–36] CortexID performs a fully automated spatial normalization applied to brain PET data without the need for same‐patient MRI coregistration. It uses rigid transforms to coregister and reslice PET data onto the T1 MRI template in standard Montreal Neurological Institute/International Consortium for Brain Mapping (MNI/ICBM) 152 space.…”
Section: Methodsmentioning
confidence: 99%