Low and mismatched socioeconomic status between newlyweds increased their risk of depressive symptoms: A multi-center study

Gan, Hong; Li, Mengdie; Wang, Xiaorui; Yang, Qianhui; Tang, Ying; Wang, Baolin; Liu, Kaiyong; Zhu, Peng; Shao, Shanshan; Tao, Fangbiao

doi:10.3389/fpsyt.2022.1038061

Cited by 4 publications

(4 citation statements)

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“…Research has indicated a significant interdependence between health behaviors and depressive symptoms among partners in a couple ( Yang et al , 2023 ). Depressive symptoms in one partner significantly impact depressive symptoms in the other ( Tower and Kasl, 1995 ), which is also supported by data from our previous study ( Gan et al , 2022 ). However, the ability to conceive depends on the couple, not merely the man or the woman.…”

Section: Introductionsupporting

confidence: 89%

Preconception depression reduces fertility: a couple-based prospective preconception cohort

Liao,

Gao,

Yang

et al. 2024

Human Reproduction Open

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STUDY QUESTION Is preconception depression associated with time to pregnancy (TTP) and infertility? SUMMARY ANSWER Couples with preconception depression needed a longer time to become pregnant and exhibited an increased risk of infertility. WHAT IS KNOWN ALREADY Preconception depression in women contributes to impaired fertility in clinical populations. However, evidence from the general population—especially based on couples—is relatively scant. STUDY DESIGN, SIZE, DURATION A couple-based prospective preconception cohort study was performed in 16 premarital examination centers between April 2019 and June 2021. The final analysis included 16,521 couples who tried to conceive for ≤6 months at enrollment. Patients with infertility were defined as those with a TTP ≥12 months and those who conceived through ART. PARTICIPANTS/MATERIALS, SETTING, METHODS Couples’ depression was assessed using the Patient Health Questionnaire-9 at baseline. Reproductive outcomes were obtained via telephone at 6 and 12 months after enrollment. Fertility odds ratios (FORs) and infertility risk ratios (RRs) in different preconception depression groups were analysed using the Cox proportional-hazard models and logistic regression, respectively. MAIN RESULTS AND THE ROLE OF CHANCE Of the 16,521 couples analyzed, 10,834 (65.6%) and 746 (4.5%) couples achieved pregnancy within the first 6 months and between the 6th and 12th months, respectively. The median (P25, P75) TTP was 3.0 (2.0, 6.0) months. The infertility rate was 13.01%. After adjusting for potential confounders, in the individual-specific analyses, we found that preconception depression in women was significantly related to reduced odds of fertility (FOR = 0.947, 95% CI: 0.908–0.988), and preconception depression in either men or women was associated with an increased risk of infertility (women: RR = 1.212, 95%CI: 1.076–1.366; men: RR = 1.214, 95%CI: 1.068–1.381); in the couple-based analyses, we found that—compared to couples where neither partner had depression—the couples where both partners had depression exhibited reduced fertility (adjusted FOR = 0.904, 95%CI: 0.838–0.975). The risk of infertility in the group where only the woman had depression and both partners had depression increased by 17.8% (RR = 1.178, 95%CI: 1.026–1.353) and 46.9% (RR = 1.469, 95%CI: 1.203–1.793), respectively. LIMITATIONS, REASONS FOR CAUTION Reporting and recall bias were unavoidable in this large epidemiological study. Some residual confounding factors—such as the use of anti-depressants and other medications, sexual habits, and prior depressive and anxiety symptoms—remain unaddressed. We used a cut-off score of 5 to define depression, which is lower than prior studies. Finally, we assessed depression only at baseline, therefore we could not detect effects of temporal changes in depression on fertility. WIDER IMPLICATIONS OF THE FINDINGS This couple-based study indicated that preconception depression in individuals and couples negatively impacts couples’ fertility. Early detection and intervention of depression to improve fertility should focus on both sexes. STUDY FUNDING/COMPETING INTEREST(S) This work was supported by grants from the National Natural Science Foundation of China (No. 82273638) and the National Key Research and Development Program of China (No. 2018YFC1004201). All authors declare no conflicts of interest. TRIAL REGISTRATION NUMBER N/A.

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Section: Introductionsupporting

confidence: 89%

Preconception depression reduces fertility: a couple-based prospective preconception cohort

Liao,

Gao,

Yang

et al. 2024

Human Reproduction Open

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“…The study aims to identify the independent and combined effects of pre-pregnancy lifestyles and environmental exposure on infertility, adverse pregnancy outcomes, and offspring growth and development. More details are given in our previous literature ( 25 ). We recruited 33,687 couples (33,271 men, 33,354 women, and 32,938 husband-wife dyads) from 16 sites in Anhui Province from April 2019 to June 2021.…”

Section: Methodsmentioning

confidence: 99%

Association between behavioral patterns and depression symptoms: dyadic interaction between couples

Yang,

Gao,

Tang

et al. 2023

Front. Psychiatry

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BackgroundBehavioral patterns are sometimes associated with depression symptoms; however, few studies have considered the intra-couple effects. This study examined the effect of a spouses’ behavioral patterns on depression symptoms within themself and in their spouse.MethodsA total of 61,118 childbearing age participants (30,559 husband-wife dyads) were surveyed. The depression symptoms were assessed using the nine-item Patient Health Questionnaire (PHQ-9). The behavioral patterns were identified by the latent class analysis. The effects of behavioral patterns on the couple’s own depression symptoms (actor effect) and their partner’s depression symptoms (partner effect) were analyzed using the Actor-Partner Interdependence Model (APIM).ResultsThree behavioral patterns were identified: low-risk group, moderate-risk group, and high-risk group. The high risk of these behavior patterns would be associated with a higher score on the PHQ-9; for both husbands and wives, their behavioral patterns were positively associated with PHQ-9 scores (βhusband = 0.53, P < 0.01; βwife = 0.58, P < 0.01). Wives’ behavioral patterns were also positively associated with their husbands’ PHQ-9 scores (β = 0.14, P < 0.01), but husbands’ behavioral patterns were not associated with their wives’ PHQ-9 scores.ConclusionsWives’ depression symptoms were affected only by their own behavioral patterns, whereas husbands’ depression symptoms were influenced by both their own and their spouses’ behavioral patterns.

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“…RHCC-AC was divided into two subcohorts: the rst subcohort was the newlyweds cohort, and the second was the infertility-speci c cohort. The details of the newlywed cohort study are described elsewhere [29]. An infertility-speci c cohort was initiated in December 2020, and couples who had not conceived within 12 months after stopping the use of contraception at the infertility clinic of Ma'anshan Maternal and Child Health Hospital and 901 Hospital of People's Liberation Army were included in this prospective study.…”

Section: Study Design and Populationmentioning

confidence: 99%

“…Depressive symptoms were evaluated by the Patient Health Questionnaire 9 (PHQ-9). The details of the evaluation of depressive symptoms are described elsewhere [29].…”

Section: Questionnaires and Collection Of General Datamentioning

confidence: 99%

Mediating effects of DNA methylation on the association of sleep quality with infertility among women of childbearing age

Tang

Gan

Wang

et al. 2023

Preprint

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Background To investigate the association between sleep quality and infertility in Chinese females and to explore the mediating effects of DNA methylation. Methods This study was based on the Reproductive Health of Childbearing Couples - Anhui Cohort (RHCC-AC) study in China. We used the Illumina Infinium Human Methylation 850k BeadChip to detect changes in DNA methylation in peripheral blood samples. Here, we compared the relationship between female sleep characteristics and infertility in females with anovulatory infertility (n = 43) and healthy female controls (n = 43). A total of 753 354 CpG sites were included in the final analysis. We identified differentially methylated sites between cases and controls using the R package ChAMP. The R package “mediation” Bayesian estimation method was used to investigate the mediation effect between sleep quality and infertility among women. Results Of the 753 354 probes on the EPIC Beadchips analyzed, a total of 763 differentially methylated CpG sites corresponding to 476 genes were identified, including 540 hypermethylated sites and 223 hypomethylated sites. Difficulty falling asleep was a risk factor for infertility in females, and a causal mediation effect of DNA methylation sites was found (cg07675898, cg08298632 and cg15500907). Conclusions These results suggest that DNA methylation sites play a significant role between difficulty falling asleep and infertility in women, and a total of three methylation sites (cg07675898, cg08298632 and cg15500907) were found to be mediating variables. With the help of causal mediation analysis, the mediation effect of DNA methylation between difficulty falling asleep and female infertility provided new clues for the prevention and treatment of female infertility.

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Low and mismatched socioeconomic status between newlyweds increased their risk of depressive symptoms: A multi-center study

Cited by 4 publications

References 40 publications

Preconception depression reduces fertility: a couple-based prospective preconception cohort

Preconception depression reduces fertility: a couple-based prospective preconception cohort

Association between behavioral patterns and depression symptoms: dyadic interaction between couples

Mediating effects of DNA methylation on the association of sleep quality with infertility among women of childbearing age

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