Low anterior resection syndrome following rectal cancer surgery: are incidence and severity lower with long-term follow-up?

Parnasa, Shani; Chill, Henry H.; Helou, Briggite; Cohen, Adiel; Alter, Roie; Shveiky, David; Mizrahi, Ido; Abu-Gazala, Mahmoud; Pikarsky, Alon J.; Shussman, Noam

doi:10.1007/s10151-022-02699-6

Cited by 6 publications

(1 citation statement)

References 30 publications

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“…Finally, to compare our findings with those presented in the literature, Parnasa et al [ 32 ] published a retrospective single-center study of 240 patients in 2022, obtaining results similar to ours: a smaller distance from the anal verge, neoadjuvant radiotherapy and TME (versus partial mesorectal excision and, therefore, a more conservative approach on the hypogastric nerves) resulted as independent prognostic factors for LARS. He et al in 2022 [ 33 ] conducted a post hoc analysis on 327 patients subjected to chemotherapy followed by sphincter-saving proctectomy.…”

Section: Discussionsupporting

confidence: 85%

Low Anterior Resection Syndrome (LARS) after Surgery for Rectal Cancer: An Inevitable Price to Pay for Survival, or a Preventable Complication?

Muttillo,

La Franca,

Coppola

et al. 2023

JCM

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Background: Rectal cancer is frequent and often treated with sphincter-saving procedures that may cause LARS, a syndrome characterized by symptoms of bowel disfunction that may severely affect quality of life. LARS is common, but its pathogenesis is mostly unknown. The aim of this study is to assess the incidence of LARS and to identify potential risk factors. Methods: We performed an observational retrospective single center analysis. The following data were collected and analyzed for each patient: demographics, tumor-related data, and intra- and peri-operative data. Statistical analysis was conducted, including descriptive statistics and multivariate logistic regression to identify independent risk factors. Results: Total LARS incidence was 31%. Statistically significant differences were found in tumor distance from anal verge, tumor extension (pT and diameter) and tumor grading (G). Multivariate analysis identified tumor distance from anal verge and tumor extension as an independent predictive factor for both major and total LARS. Adjuvant therapy, although not significant at univariate analysis, was identified as an independent predictive factor. Time to stoma closure within 10 weeks seems to reduce incidence of major LARS. Conclusions:bold LARS affects a considerable portion of patients. This study identified potential predictive factors that could be useful to identify high risk patients for LARS.

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Section: Discussionsupporting

confidence: 85%