Low anterior resection syndrome – ‘braking’ our focus with the pelvis

Burke, John P.

doi:10.1111/codi.15548

Cited by 3 publications

(3 citation statements)

References 6 publications

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“…This scoring system ranged from 18–90, higher scores indicate better levels of bowel function. However, this scoring system was not universally applicable and could not be widely used ( 1 , 14 , 36 ). The second idea of LARS scoring system which had five-item validated questionnaire evaluating the bowel functions after CRC surgery in 2012, and this questionnaire has been used to evaluate LARS worldwide.…”

Section: Discussionmentioning

confidence: 99%

The risk factors of low anterior resection syndrome after colorectal cancer surgery: A retrospective study of 566 patients in a single institution in China

Kang

et al. 2022

Front. Surg.

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PurposeThis study aims to identify the independent risk factors in the low anterior resection syndrome (LARS) after surgery for colorectal cancer (CRC).MethodThis was a retrospective, single-institution study in the Second Affiliation Hospital of Dalian Medical University, China. Patients underwent sphincter-preserving low anterior resection with total or partial mesorectal resection (with or without protective ileostomy) and completed a self-filled questionnaire over the phone to assess postoperative bowel dysfunction from January 2017 to December 2019. The predictors of LAR were evaluated using univariate and multivariate analyses.ResultThe study population was 566 patients, 264 (46.64%), 224 (39.58%), and 78 (13.78%) patients with no, minor, and major LARS, respectively. In the univariate analysis, independent factors such as tumor location and size, anastomotic height, protective ileostomy, post-operation chemoradiotherapy, tumor T stage, lymphatic nodal metastasis classification, surgery duration, and time interval for closure of stoma were significantly associated with LARS points while we found the tumor T stage and lymphatic nodal metastasis classification as the new independent risk factors compared with the last decade studies. In the multivariate analysis, factors such as low and middle tumor location and protective ileostomy, and post operation treatment, nodal metastasis classification were the independent risk factors for major LARS.ConclusionThe new independence risk factors were tumor T stage and lymphatic nodal metastasis status in univariate analysis in our study, with anastomotic height, low and middle tumor location, protective ileostomy, post-operation chemoradiotherapy, nodal metastasis status increasing LARS point in multivariate analysis after surgery for CRC.

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Section: Discussionmentioning

confidence: 99%

The risk factors of low anterior resection syndrome after colorectal cancer surgery: A retrospective study of 566 patients in a single institution in China

Kang

et al. 2022

Front. Surg.

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“…Every item has three options with a de ned scoring system used for evaluating the severity. The patients were divided into the no (0-20), minor (21)(22)(23)(24)(25)(26)(27)(28)(29), and major (30-42) LARS groups depending on their total score (Table 2). We used the Chinese version of the questionnaire.…”

Section: Lars Questionnaire and Data Collectionmentioning

confidence: 99%

“…This scoring system ranged from 18 to 90, higher scores indicate better levels of bowel function. However, this scoring system was not universally applicable and could not be widely used [1,16,24]. The second LARS scoring system is a veitem validated questionnaire created in 2012 for the Danish population that evaluates the bowel function after CRC surgery (Table 1) [5,25,26].…”

Section: Introductionmentioning

confidence: 99%

The Risk Factors of Low Anterior Resection Syndrome After Colorectal Cancer Surgery Compared with the Last Decade Studies

Kim

et al. 2022

Preprint

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Purpose This study aims to identify the independent risk factors compared with the last decade studies in the low anterior resection syndrome (LARS) after surgery for colorectal cancer (CRC). Method This was a cross-sectional, single-institution study in the Second Affiliation Hospital of Dalian Medical University, China. Patients underwent sphincter-preserving low anterior resection with total or partial mesorectal resection (with or without protective ileostomy) and completed a self-filled questionnaire over the phone to assess postoperative bowel dysfunction from January 2017 to December 2019. The predictors of LAR were evaluated using univariate and multivariate analyses, and compared with the last decade studies. Result The study population was 566 patients, 264 (46.64%), 224 (39.58%), and 78 (13.78%) patients with no, minor, and major LARS, respectively. In the univariate analysis, independent factors such as tumor location and size, anastomotic height, protective ileostomy, post-operation chemoradiotherapy, tumor T stage, lymphatic nodal metastasis classification, surgery duration, and time interval for closure of stoma were significantly associated with LARS points while we found the tumor T stage and lymphatic nodal metastasis classification as the new independent risk factors compared with the last decade studies. in the multivariate analysis, factors such as low and middle tumor location and protective ileostomy, and post operation treatment, nodal metastasis classification were the independent risk factors for major LARS. Conclusion The new independence risk factors were tumor T stage and lymphatic nodal metastasis status in univariate analysis in our study, with anastomotic height, low and middle tumor location, protective ileostomy, post-operation chemoradiotherapy, nodal metastasis status increasing LARS point in multivariate analysis after surgery for CRC.

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Development and validation of an MRI and clinicopathological factors prediction model for low anterior resection syndrome in anterior resection of middle and low rectal cancer

Wang,

Zhou,

Meng

et al. 2024

Heliyon

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Low anterior resection syndrome – ‘braking’ our focus with the pelvis

Cited by 3 publications

References 6 publications

The risk factors of low anterior resection syndrome after colorectal cancer surgery: A retrospective study of 566 patients in a single institution in China

The risk factors of low anterior resection syndrome after colorectal cancer surgery: A retrospective study of 566 patients in a single institution in China

The Risk Factors of Low Anterior Resection Syndrome After Colorectal Cancer Surgery Compared with the Last Decade Studies

Development and validation of an MRI and clinicopathological factors prediction model for low anterior resection syndrome in anterior resection of middle and low rectal cancer

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