Low-antigen-content diet in the treatment of patients with IgA nephropathy

Ferri, Claudio; Puccini, R; Longombardo, G.; Paleologo, G; Migliorini, Paola; Moriconi, L; Pasero, G; Cioni, L

doi:10.1007/bf00866368

Cited by 14 publications

(16 citation statements)

References 14 publications

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“…Kovacs et al [43] have demonstrated that in patients with a higher degree of deterioration of the renal function, the intestinal permeability has also increased and, therefore, may play a role in the pathogenesis of the disease and adversely influence its progression. The intestinal mucosa has an absorptive function and acts as a selective barrier against potential antigenic, toxic, and carcinogenic substances, and a low-antigen diet may favorably influence the progression of IgA NP [21]. In the patients described by Kovacs et al [44] with increased intestinal permeability, also significantly elevated IgA antibody titers against gliadin, soy, and other dietary antigens as compared with controls were found.…”

Section: Discussionmentioning

confidence: 65%

IgA-Antigliadin Antibodies in Patients with IgA Nephropathy: The Secondary Phenomenon?

Ots¹,

Uibo²,

Metsküla

et al. 1999

Am J Nephrol

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Circulating IgA-antigliadin antibodies (IgA-AGA) are often found in patients with IgA nephropathy (NP). IgA-AGA are sensitive markers of an abnormal immune system reaction to gluten, seen particularly in patients with celiac disease. However, a lack of IgA-antireticulin and IgA-antiendomysium antibodies and often jejunal mucosal atrophy of patients with IgA NP suggest that most patients do not have latent celiac disease. To examine the relationship between IgA-AGA and clinical data, enzyme-linked immunosorbent assays for IgA-AGA were performed in 28 patients with IgA NP and in 50 healthy persons. The results were calculated in arbitrary units (AU). The cutoff level for a negative or a positive test was found to be 60 AU, calculated according to the AGA test result (mean + 3 SD) in 50 healthy persons. The following clinical data were assessed: age, gender, disease duration, daily proteinuria, blood pressure, serum creatinine, and creatinine clearance. Control sera were negative for IgA-AGA. Positive IgA-AGA tests were observed in 14 of the 28 patients (p < 0.0001 vs. controls) and high levels of IgA-AGA (AU >90) in 6 of the 28 patients (p < 0.001 vs. controls). The mean duration of the disease of the patients with positive IgA-AGA was significantly longer as compared with the patients who had a negative antibody test. IgA-AGA correlated with age (p < 0.05, r = 0.56), disease duration (p < 0.05, r = 0.40), and blood pressure (p < 0.05, r = 0.48). Antireticulin and antiendomysium antibody tests were negative in all patient and control sera. We conclude that IgA-AGA are associated with the progression of IgA NP. Our findings support the current concept about the pathogenesis of IgA NP, where the defective IgA production itself may be the primary and intestinal lesions as well as the production of IgA-AGA the secondary phenomenon.

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Section: Discussionmentioning

confidence: 65%

IgA-Antigliadin Antibodies in Patients with IgA Nephropathy: The Secondary Phenomenon?

Ots¹,

Uibo²,

Metsküla

et al. 1999

Am J Nephrol

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“…When given to 21 consecutive patients with IgAN, protein excretion fell markedly in all 12 patients whose baseline rate was more than 1g/day. In addition, repeat renal biopsy showed significant reductions in mesangial IgA and complement deposition and mesangial cellularity [Ferri et al, 1993]. However, the benefits in the above study have not been confirmed and a report using a gluten-free diet alone for several years was unable to document improvement in either proteinuria or renal function despite a reduction in the level of circulating IgA-containing immune complexes [Coppo et al, 1990].…”

Section: Other Possible Interventionsmentioning

confidence: 93%

IgA Nephropathy: Insights into Genetic Basis and Treatment Options

Kirmizis¹,

Papagianni²,

Schena³

2011

An Update on Glomerulopathies - Clinical and Treatment Aspects

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“…Several diets were investigated and suggested for patients with IgAN as Mediterranean diet [56], low-antigen diet [a diet free of foods likely to cause an allergic reaction] [57] and fish oil (KDIGO recommendations) [25].…”

Section: Other Dietsmentioning

confidence: 99%

Gluten, Transglutaminase, Celiac Disease and IgA Nephropathy

Lerner¹,

Berthelot²,

Jeremias³

et al. 2017

J Clin Cell Immunol

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Both, celiac disease and IgA nephropathy are autoimmune diseases that are IgA mediated and share multiple clinical, pathophysiological, genetic, nutritional and immunological aspects. In view of recent observations and wider understanding of the central role played by the intestinal ecosystem in celiac disease and IgA nephropathy development, the present review highlights those shared aspects, concentrating on potential nutritional therapeutic strategies in IgA nephropathy.

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Low-antigen-content diet in the treatment of patients with IgA nephropathy

Cited by 14 publications

References 14 publications

IgA-Antigliadin Antibodies in Patients with IgA Nephropathy: The Secondary Phenomenon?

IgA-Antigliadin Antibodies in Patients with IgA Nephropathy: The Secondary Phenomenon?

IgA Nephropathy: Insights into Genetic Basis and Treatment Options

Gluten, Transglutaminase, Celiac Disease and IgA Nephropathy

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