Low arterial blood oxygenation is associated with calcification of the coronary arteries in patients with chronic obstructive pulmonary disease

Inoue, Sumito; Shibata, Yoko; Kishi, Hiroyuki; Hasegawa, Hiromasa; Nitobe, Joji; Iwayama, Tadateru; Yashiro, Yoshinori; Nemoto, Takako; Sato, Kento; Nakano, Hiroshi; Sato, Masamichi; Nunomiya, Keiko; Aida, Yasuko; Yamauchi, Keiko; Igarashi, Akira; Abe, Shuichi

doi:10.1016/j.resinv.2015.01.002

Cited by 3 publications

(2 citation statements)

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“…Cardiac CT scanning allows the evaluation of atherosclerotic regions of the coronary arteries, and we previously reported that calcification in the coronary arteries is associated with low-grade oxygenation in patients with stable COPD. 23 …”

Section: Discussionmentioning

confidence: 99%

“… 21–23 This protocol was the same as that used in a previously reported study. 23 An automatic algorithm in the analysis software (ZIO station, ZIO soft, Tokyo, Japan) was used 20 22 to evaluate cardiac volumes and output. The patients' profiles, respiratory function and cardiac parameters measured by MDCT or echocardiography are summarised in table 1 .…”

Section: Methodsmentioning

confidence: 99%

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Decreased left ventricular stroke volume is associated with low-grade exercise tolerance in patients with chronic obstructive pulmonary disease

et al. 2017

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BackgroundLow-grade exercise tolerance is associated with a poor prognosis in patients with chronic obstructive pulmonary disease (COPD). The 6 min walk test (6MWT) is commonly used to evaluate exercise tolerance in patients with COPD. However, little is known regarding the relationship between cardiac function and exercise tolerance in patients with COPD. The aim of this study was to identify predictive factors in cardiac function for low-grade exercise tolerance in patients with stable COPD.MethodsWe recruited 57 patients with stable COPD (men 54, women 3) to perform the 6MWT. Patients with underlying orthopaedic disease or heart failure were excluded. Cardiac function was evaluated by echocardiography and contrast-enhanced cardiac CT. We also measured pulmonary function and the 6MWT distance.ResultsForced expiratory volume in 1 s (FEV1) and per cent predicted FEV, along with left ventricular end diastolic volume and left ventricular cardiac output as measured by cardiac CT, were significantly related to the 6MWT distance. On multivariate analysis, left ventricular stroke volume was the factor most closely associated with a decreased walked distance in the 6MWT.ConclusionsDecreased left ventricular stroke volume was associated with low-grade exercise tolerance in patients with stable COPD without heart failure.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Decreased left ventricular stroke volume is associated with low-grade exercise tolerance in patients with chronic obstructive pulmonary disease

et al. 2017

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Hypoxia and panvascular diseases: exploring the role of hypoxia-inducible factors in vascular smooth muscle cells under panvascular pathologies

Zhao

et al. 2023

Science Bulletin

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Hypoxia Triggers Osteochondrogenic Differentiation of Vascular Smooth Muscle Cells in an HIF-1 (Hypoxia-Inducible Factor 1)–Dependent and Reactive Oxygen Species–Dependent Manner

Balogh

Tóth

Méhes

et al. 2019

ATVB

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Objective— Vascular calcification is associated with high risk of cardiovascular events and mortality. Osteochondrogenic differentiation of vascular smooth muscle cells (VSMCs) is the major cellular mechanism underlying vascular calcification. Because tissue hypoxia is a common denominator in vascular calcification, we investigated whether hypoxia per se triggers osteochondrogenic differentiation of VSMCs. Approach and Results— We studied osteochondrogenic differentiation of human aorta VSMCs cultured under normoxic (21% O 2 ) and hypoxic (5% O 2 ) conditions. Hypoxia increased protein expression of HIF (hypoxia-inducible factor)-1α and its target genes GLUT1 (glucose transporter 1) and VEGFA (vascular endothelial growth factor A) and induced mRNA and protein expressions of osteochondrogenic markers, that is, RUNX2 (runt-related transcription factor 2), SOX9 (Sry-related HMG box-9), OCN (osteocalcin) and ALP (alkaline phosphatase), and induced a time-dependent calcification of the extracellular matrix of VSMCs. HIF-1 inhibition by chetomin abrogated the effect of hypoxia on osteochondrogenic markers and abolished extracellular matrix calcification. Hypoxia triggered the production of reactive oxygen species, which was inhibited by chetomin. Scavenging reactive oxygen species by N -acetyl cysteine attenuated hypoxia-mediated upregulation of HIF-1α, RUNX2, and OCN protein expressions and inhibited extracellular matrix calcification, which effect was mimicked by a specific hydrogen peroxide scavenger sodium pyruvate and a mitochondrial reactive oxygen species inhibitor rotenone. Ex vivo culture of mice aorta under hypoxic conditions triggered calcification which was inhibited by chetomin and N -acetyl cysteine. In vivo hypoxia exposure (10% O 2 ) increased RUNX2 mRNA levels in mice lung and the aorta. Conclusions— Hypoxia contributes to vascular calcification through the induction of osteochondrogenic differentiation of VSMCs in an HIF-1–dependent and mitochondria-derived reactive oxygen species–dependent manner.

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Low arterial blood oxygenation is associated with calcification of the coronary arteries in patients with chronic obstructive pulmonary disease

Cited by 3 publications

References 29 publications

Decreased left ventricular stroke volume is associated with low-grade exercise tolerance in patients with chronic obstructive pulmonary disease

Decreased left ventricular stroke volume is associated with low-grade exercise tolerance in patients with chronic obstructive pulmonary disease

Hypoxia and panvascular diseases: exploring the role of hypoxia-inducible factors in vascular smooth muscle cells under panvascular pathologies

Hypoxia Triggers Osteochondrogenic Differentiation of Vascular Smooth Muscle Cells in an HIF-1 (Hypoxia-Inducible Factor 1)–Dependent and Reactive Oxygen Species–Dependent Manner

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