“…[4][5][6] Postoperative pain after spine procedures can be due to intrinsic and extrinsic mechanisms, which include chronic preoperative root or nerve compression and inflammation, duration and extent of the procedure, and multiple vertebral levels. 7,8 Clinical relevance of optimal pain management in these patients is further complicated by the risk for postoperative worsening of symptoms as a consequence of chronic abuse of analgesics. [9][10][11] Furthermore, in this setting, postoperative pain control is one of the major determinants of the quality of health care delivered, and it can contribute to improved functional recovery, facilitation of early mobilization and rehabilitation, and efficient resource utilization.…”