“…The intervertebral disc is the most intensively studied and characterized structure in the human spine [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ]. Despite the enormous body of literature demonstrating that disc tissues are a potent source of experimentally induced low back pain [ 23 ], for almost a century, the concept of discogenic pain as a distinct clinical entity has not been well accepted [ 4 ].…”