Low bacterial diet versus control diet to prevent infection in cancer patients treated with chemotherapy causing episodes of neutropenia

Dalen, Elvira C. van; Mank, Arno; Leclercq, Edith; Mulder, RenÃ©e L; Davies, Michelle; Kersten, M.J.; Wetering, Marianne D. van de

doi:10.1002/14651858.cd006247.pub3

Cited by 31 publications

(34 citation statements)

References 33 publications

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“…No RCT proved a benefit for prevention of infection and related outcomes. All studies had limitations regarding confounding interventions, outcome definitions, intervention and control diets [ 25 , 33 , 69 , 105 , 107 ].…”

Section: Resultsmentioning

confidence: 99%

Primary prophylaxis of invasive fungal infections in patients with haematological malignancies: 2017 update of the recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society for Haematology and Medical Oncology (DGHO)

et al. 2017

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Immunocompromised patients are at high risk of invasive fungal infections (IFI), in particular those with haematological malignancies undergoing remission-induction chemotherapy for acute myeloid leukaemia (AML) or myelodysplastic syndrome (MDS) and recipients of allogeneic haematopoietic stem cell transplants (HSCT). Despite the development of new treatment options in the past decades, IFI remains a concern due to substantial morbidity and mortality in these patient populations. In addition, the increasing use of new immune modulating drugs in cancer therapy has opened an entirely new spectrum of at risk periods. Since the last edition of antifungal prophylaxis recommendations of the German Society for Haematology and Medical Oncology in 2014, seven clinical trials regarding antifungal prophylaxis in patients with haematological malignancies have been published, comprising 1227 patients. This update assesses the impact of this additional evidence and effective revisions. Our key recommendations are the following: prophylaxis should be performed with posaconazole delayed release tablets during remission induction chemotherapy for AML and MDS (AI). Posaconazole iv can be used when the oral route is contraindicated or not feasible. Intravenous liposomal amphotericin B did not significantly decrease IFI rates in acute lymphoblastic leukaemia (ALL) patients during induction chemotherapy, and there is poor evidence to recommend it for prophylaxis in these patients (CI). Despite substantial risk of IFI, we cannot provide a stronger recommendation for these patients. There is poor evidence regarding voriconazole prophylaxis in patients with neutropenia (CII). Therapeutic drug monitoring TDM should be performed within 2 to 5 days of initiating voriconazole prophylaxis and should be repeated in case of suspicious adverse events or of dose changes of interacting drugs (BIItu). General TDM during posaconazole prophylaxis is not recommended (CIItu), but may be helpful in cases of clinical failure such as breakthrough IFI for verification of compliance or absorption.Electronic supplementary materialThe online version of this article (10.1007/s00277-017-3196-2) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Primary prophylaxis of invasive fungal infections in patients with haematological malignancies: 2017 update of the recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society for Haematology and Medical Oncology (DGHO)

et al. 2017

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“…29 This result in combination with previous similar observations argues for a less strict use of neutropenic diets. [59][60][61][62][63][64][65][66][67] Therefore, focusing on safe food-handling practices and retaining restrictions on raw meat or dairy products, as well as apparent fungal components as mold cheese, but allowing raw fruit and vegetable if properly washed and/or peeled seems adequate. 61,68 Again, only adequately powered randomized controlled studies will give better evidence on effectiveness of food safety guidelines.…”

Section: Discussionmentioning

confidence: 99%

Revisiting nutritional support for allogeneic hematologic stem cell transplantation—a systematic review

Baumgartner

Bargetzi

Zueger

et al. 2017

Bone Marrow Transplant

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In 2009, the American Society of Parenteral and Enteral Nutrition and its European counterpart (Euopean Society for Parenteral and Enteral Nutrition) published guidelines regarding nutritional support of patients with hematologic stem cell transplantation. Our aim was to do an up-to-date literature review regarding benefit of nutritional interventions and treatment recommendations. We searched MEDLINE, EMBASE and Cochrane Library for interventional and observational clinical studies. We extracted data based on a predefined case report form and assessed bias. Out of 459 potential abstracts, 13 studies of mostly moderate quality with a total of 18 167 patients were included. Two very large trials reported negative associations of malnutrition and survival, transplant-related mortality and relapse risk. Some trials found enteral nutrition (EN) to be as effective as parenteral nutrition (PN) with lower complication rates. In addition, EN was associated with better survival, less acute GvHD and faster neutrophil recovery. A neutropenic diet was not superior regarding overall survival, but in contrast resulted in higher infection risk. Current moderate quality studies show negative associations of malnutrition and clinical outcomes, with EN being superior to PN. There was no benefit of neutropenic diets. Large, randomized controlled studies are needed to better understand optimal nutritional support in this patient population.

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“…The oral cavity is a common sight of infections, often caused by bacteria, fungi, and viruses. [40] Bacterial Bacteria may be responsible for odontogenic infections. The usual symptoms are erythema, edema, and purulence.…”

Section: Osteonecrosis Of the Jawsmentioning

confidence: 99%

“…During neutropenia, it is common to observe a previously asymptomatic tooth (which has received successful endodontic treatment and has been radiographically checked), giving rise to symptoms of infection. [40] Periapical infections affect maxillary posterior teeth and if severe perforate the Schneiderian membrane and lead to sinusitis. Elimination of the infection source and antimicrobial therapy for at least three to four weeks may be necessary.…”

Section: Osteonecrosis Of the Jawsmentioning

confidence: 99%

Chemotherapy: oral side effects and dental interventions. A review of the literature

Poulopoulos¹,

Papadopoulos²,

Andreadis³

2017

SDS

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Even with the evolution of chemotherapeutic procedures and agents, chemotherapy may cause certain side effects that impair the patients' quality of life. The aim of this review is to isolate and describe the oral side effects arising only from chemotherapy and focus on the dentist's contribution to their management. This paper comprises an extensive literature review of the main side effects affecting the oral health status of patients' undergoing chemotherapy procedures. In addition, it describes the dentist's contribution in the treatment of such patients before, throughout and after antineoplastic therapy. In conclusion, the oral cavity is a usual site of discomfort and pain caused by chemotherapy, making the dentist's contribution to the patient's relief imperative. Key words:Chemotherapy, oral side effects, oral mucositis, oral infections ABSTRACTArticle history:

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Low bacterial diet versus control diet to prevent infection in cancer patients treated with chemotherapy causing episodes of neutropenia

Abstract: Low bacterial diet versus control diet to prevent infection in cancer patients treated with chemotherapy causing episodes of neutropenia.

Cited by 31 publications

References 33 publications

Primary prophylaxis of invasive fungal infections in patients with haematological malignancies: 2017 update of the recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society for Haematology and Medical Oncology (DGHO)

Primary prophylaxis of invasive fungal infections in patients with haematological malignancies: 2017 update of the recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society for Haematology and Medical Oncology (DGHO)

Revisiting nutritional support for allogeneic hematologic stem cell transplantation—a systematic review

Chemotherapy: oral side effects and dental interventions. A review of the literature

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