Low Birth Weight and Congenital Heart Disease: Current Status and Future Directions

Costello, John M.; Bradley, Scott M.

doi:10.1016/j.jpeds.2021.08.021

Cited by 7 publications

(3 citation statements)

References 14 publications

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“… 15 , 49 It is well recognized that neonates with CHD face an increased risk of LBW, potentially due to abnormal circulation during the fetal period. 50 Following birth, unstable hemodynamics can further impact the nutrition and oxygen supplementation until anatomical correction, which may worsen the somatic growth. Moreover, a prospective study revealed that infants with LBW would continue to suffer significant malnutrition even after corrective surgery.…”

Section: Discussionmentioning

confidence: 99%

Failure to thrive in pediatric patients with congenital heart disease: a cross-sectional study of 13,256 patients

He,

Lin,

Zhou

et al. 2024

The Lancet Regional Health - Western Pacific

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Section: Discussionmentioning

confidence: 99%

Failure to thrive in pediatric patients with congenital heart disease: a cross-sectional study of 13,256 patients

He,

Lin,

Zhou

et al. 2024

The Lancet Regional Health - Western Pacific

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“…Low birth weight is becoming a factor that independently associated with underweight and stunting among children with CHD in this study. Neonates with CHD are at greater risk for being born with low birth weight, premature, and small for gestational age [ 31 , 32 ]. A meta-analysis suggests that various alterations in fetal hemodynamics and oxygen saturation due to CHD are the root causes of this association, such as reduced ventricular function that decreases cardiac output resulting in stunted fetal growth [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Outcome and factors associated with undernutrition among children with congenital heart disease

et al. 2023

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Background Congenital heart disease (CHD) is associated with high morbidity and mortality, especially among those with undernutrition. Evaluating risk factors associated with undernutrition is important to improve clinical outcomes. We aimed to evaluate the outcome and factors associated with undernutrition among children with CHD. Material and methods A prospective cohort study was conducted among children with CHD at Dr. Sardjito Hospital, Yogyakarta, Indonesia during February 2016 to June 2018. Clinical and demographic data were collected at the time of diagnosis. Multivariate logistic regression analysis was used to identify independent factors associated with undernutrition using odds ratio (OR) and 95% confidence interval (CI). Significance was set as p<0.05. Results We recruited 1,149 children with CHD, of those, 563 (49%) were underweight, 549 (47.8%) were stunting, and 361 (31.4%) were wasting. In the multivariate analysis, cyanotic CHD, delayed diagnosis, congestive heart failure, pulmonary hypertension, syndrome, young maternal age, history of low birth weight, and being first child were independently associated with undernutrition. Underweight and stunting were significantly associated with increased mortality with OR of 3.54 (95% CI: 1.62–7.74), p<0.001 and OR 3.31 (95% CI: 1.65–6.64), p<0.001, respectively. Conclusions About half of the children with CHD were categorized with undernutrition. An increased risk of undernutrition was associated with cyanotic CHD, delayed diagnosis, congestive heart failure, pulmonary hypertension, syndrome, low birth weight, and being first child. Underweight and stunting were significantly associated with increased risk of death.

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“…This is because infants with CHD have higher rates of low birth weight or small for gestational age (SGA) than healthy newborns. 6 7 8 Children with CHD also have a higher rate of nutritional deficiencies and increased metabolic demands, which lead to GR. 9 10 …”

Section: Introductionmentioning

confidence: 99%

Neonatal Risk Factors for Growth Retardation in Infants With Congenital Heart Disease

2023

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Background While the association of congenital heart disease (CHD) and growth retardation (GR) is known, data remain limited. This study investigated the incidence of GR and its neonatal risk factors in patients with CHD using nationwide population-based claims data. Method The study population was extracted from Korean National Health Insurance Service claims data from January 2002 to December 2020. We included patients diagnosed with CHD under one year of age. GR was defined as an idiopathic growth hormone deficiency or short stature on the claims data. We investigated the neonatal risk factors for GR. Results The number of patients diagnosed with CHD within the first year of birth was 133,739. Of these, 2,921 newborns were diagnosed with GR. The cumulative incidence of GR was 4.8% at 19 years of age for individuals diagnosed with CHD at infancy. In the multivariable analysis, the significant risk factors for GR were preterm birth, small for gestational age, low birth weight, respiratory distress, bronchopulmonary dysplasia, bacterial sepsis, necrotizing enterocolitis, feeding problems and cardiac procedure. Conclusion Several neonatal conditions were significant risk factors for GR in CHD patients, and appropriate monitoring and treatment programs are required in CHD neonates with these factors. Considering this study is limited to claims data, further studies are warranted, including genetic and environmental factors affecting GR in CHD patients.

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Low Birth Weight and Congenital Heart Disease: Current Status and Future Directions

Cited by 7 publications

References 14 publications

Failure to thrive in pediatric patients with congenital heart disease: a cross-sectional study of 13,256 patients

Failure to thrive in pediatric patients with congenital heart disease: a cross-sectional study of 13,256 patients

Outcome and factors associated with undernutrition among children with congenital heart disease

Neonatal Risk Factors for Growth Retardation in Infants With Congenital Heart Disease

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