Low birth weight and risk of high blood pressure in adulthood

Gennser, G.; Rymark, Per; Isberg, Per Erik

doi:10.1136/bmj.296.6635.1498

Cited by 187 publications

(89 citation statements)

References 18 publications

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“…1,[21][22][23] Other studies have demonstrated only a weak 24 or no significant support of this association. 25 In a recent analysis of follow-up data, Hack et al 26,27 reported lower blood …”

Section: Discussionmentioning

confidence: 99%

Birth Weight Versus Childhood Growth as Determinants of Adult Blood Pressure

1998

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Abstract-In older white American adults, recent retrospective studies have demonstrated a relationship between lower birth weight and hypertension. Black Americans have a higher occurrence of both lower birth weight and hypertension than do white Americans. To test the low birth weight-high blood pressure hypothesis, data from a prospective study (Perinatal Collaborative Project) were examined. The study followed a sample of 137 black Americans, with nine examinations. Data on birth weight, growth, and blood pressure from birth through 28.0Ϯ2.7 years were obtained longitudinally. Bivariate correlations among parameters were computed with the Pearson r. Birth weight and blood pressure at age 28 years are not correlated (Pearson rϭ.06). However, systolic blood pressures measured at 0.3 years and thereafter are correlated with adult systolic blood pressure. Also, weight at 0.3 years and body mass index at 7 years and thereafter are correlated with adult weight. Our data did not confirm the birth weight-blood pressure hypothesis. Rather, we detected significant correlations between preadult measurements of blood pressure and weight with adult measurements. These results indicate that in black Americans, childhood growth is a stronger determinant than intrauterine growth of adult blood pressure.

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Section: Discussionmentioning

confidence: 99%

Birth Weight Versus Childhood Growth as Determinants of Adult Blood Pressure

1998

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“…30 This was followed by a number of observations of a negative association between birthweight and blood pressure. [31][32][33][34] Researchers led by Barker then discovered a link between birthweight and risk of cardiovascular disease more generally. [35][36][37][38] Since then, additional findings have evolved into the "Developmental Origins of Health and Disease" hypothesis, which states that during critical periods of prenatal and postnatal mammalian development, nutrition and other environmental stimuli can influence developmental pathways, thereby inducing permanent changes in metabolism and chronic disease susceptibility.…”

Section: Resultsmentioning

confidence: 99%

Expression discordance of monozygotic twins at birth: Effect of intrauterine environment and a possible mechanism for fetal programming

Gordon¹,

Joo²,

Andronikos³

et al. 2011

Epigenetics

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“…For instance, several human studies have shown that birth weight is inversely associated with blood pressure in childhood, as well as in adult life (8)(9)(10)(11)(12)(13)(14), but this association has not been confirmed by all investigators (15)(16)(17). In their experimental studies, Langley and co-workers (18) showed that rats exposed to a low-protein diet in utero exhibited lower body weight at birth and higher systolic blood pressure at 4 weeks of age.…”

Section: Introductionmentioning

confidence: 94%

Influence of a multideficient diet from northeastern Brazil on resting blood pressure and baroreflex sensitivity in conscious, freely moving rats

Monteiro

Lahlou

Albuquerque

et al. 2001

Braz J Med Biol Res

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The regional basic diet or RBD is a multideficient diet (providing 8% protein) which is known to produce dietary deficiencies in some populations in northeastern Brazil. The present study investigated the effects of RBD-induced malnutrition on resting blood pressure and baroreflex sensitivity in conscious rats. Malnourished rats were obtained by feeding dams the RBD during mating and pregnancy (RBD-1 group) or during nursing and a 10-day period after weaning (RBD-2 group). At 90 days of age, only RBD-2 rats weighed significantly (P<0.001) less than control rats born to dams fed a standard commercial diet (23% protein) during pregnancy and nursing. Baseline mean arterial pressure and heart rate of both RBD-1 and RBD-2 rats were comparable to those of controls. The slopes for both reflex bradycardia and tachycardia (bpm/mmHg) induced by intravenous phenylephrine and sodium nitroprusside, respectively, were unchanged in either RBD-1 (-2.08 ± 0.11 and -3.10 ± 0.43, respectively) or RBD-2 (-2.32 ± 0.30 and -3.73 ± 0.53, respectively) rats, when compared to controls (-2.09 ± 0.10 and -3.17 ± 0.33, respectively). This study shows that, after a prolonged period of nutritional recovery, the patterns of resting blood pressure and baroreflex sensitivity of both pre-and postnatally malnourished rats were similar to those of controls. The decreased body weight and the tendency to increased reflex tachycardia in RBD-2 rats may suggest that this type of maternal malnutrition during lactation is more critical than during pregnancy. Correspondence

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Low birth weight and risk of high blood pressure in adulthood

Cited by 187 publications

References 18 publications

Birth Weight Versus Childhood Growth as Determinants of Adult Blood Pressure

Birth Weight Versus Childhood Growth as Determinants of Adult Blood Pressure

Expression discordance of monozygotic twins at birth: Effect of intrauterine environment and a possible mechanism for fetal programming

Influence of a multideficient diet from northeastern Brazil on resting blood pressure and baroreflex sensitivity in conscious, freely moving rats

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